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The Challenge of Die Filling in Rotary Presses—A Systematic Study of Material Properties and Process Parameters
Open AccessArticle

Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical Excipients in Rotary Tablet Presses

1
Institute for Particle Technology, Technische Universität Braunschweig, Volkmaroder Str. 5, 38104 Braunschweig, Germany
2
Center of Pharmaceutical Engineering (PVZ), Technische Universität Braunschweig, Franz-Liszt-Str. 35A, 38106 Braunschweig, Germany
3
KORSCH AG, Breitenbachstr. 1, 13509 Berlin, Germany
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(3), 283; https://doi.org/10.3390/pharmaceutics12030283
Received: 28 February 2020 / Revised: 18 March 2020 / Accepted: 19 March 2020 / Published: 21 March 2020
(This article belongs to the Special Issue Powder Processing in Pharmaceutical Applications)
Paddle feeders are devices commonly used in rotary tablet presses to facilitate constant and efficient die filling. Adversely, the shear stress applied by the rotating paddles is known to affect the bulk properties of the processed powder dependent on the residence time. This study focuses on the residence time distribution (RTD) of two commonly applied excipients (microcrystalline cellulose, MCC; dicalcium phosphate, DCP), which exhibit different flow properties inside rotary tablet presses. To realistically depict the powder flow inside rotary tablet presses, custom-made tracer powder was developed. The applied method was proven to be appropriate as the tracer and bulk powder showed comparable properties. The RTDs of both materials were examined in two differently scaled rotary tablet presses and the influence of process parameters was determined. To analyze RTDs independent of the mass flow, the normalized variance was used to quantify intermixing. Substantial differences between both materials and tablet presses were found. Broader RTDs were measured for the poorer flowing MCC as well as for the production scale press. The obtained results can be used to improve the general understanding of powder flow inside rotary tablet presses and amplify scale-up and continuous production process development. View Full-Text
Keywords: tableting; powder flow; feed frame; scale-up; intermixing tableting; powder flow; feed frame; scale-up; intermixing
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MDPI and ACS Style

Puckhaber, D.; Eichler, S.; Kwade, A.; Finke, J.H. Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical Excipients in Rotary Tablet Presses. Pharmaceutics 2020, 12, 283.

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