Next Article in Journal
A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice
Next Article in Special Issue
Scaling Tableting Processes from Compaction Simulator to Rotary Presses—Mind the Sub-Processes
Previous Article in Journal
Topical Delivery of Meloxicam using Liposome and Microemulsion Formulation Approaches
Previous Article in Special Issue
The Challenge of Die Filling in Rotary Presses—A Systematic Study of Material Properties and Process Parameters
Open AccessArticle

Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical Excipients in Rotary Tablet Presses

Institute for Particle Technology, Technische Universität Braunschweig, Volkmaroder Str. 5, 38104 Braunschweig, Germany
Center of Pharmaceutical Engineering (PVZ), Technische Universität Braunschweig, Franz-Liszt-Str. 35A, 38106 Braunschweig, Germany
KORSCH AG, Breitenbachstr. 1, 13509 Berlin, Germany
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(3), 283;
Received: 28 February 2020 / Revised: 18 March 2020 / Accepted: 19 March 2020 / Published: 21 March 2020
(This article belongs to the Special Issue Powder Processing in Pharmaceutical Applications)
Paddle feeders are devices commonly used in rotary tablet presses to facilitate constant and efficient die filling. Adversely, the shear stress applied by the rotating paddles is known to affect the bulk properties of the processed powder dependent on the residence time. This study focuses on the residence time distribution (RTD) of two commonly applied excipients (microcrystalline cellulose, MCC; dicalcium phosphate, DCP), which exhibit different flow properties inside rotary tablet presses. To realistically depict the powder flow inside rotary tablet presses, custom-made tracer powder was developed. The applied method was proven to be appropriate as the tracer and bulk powder showed comparable properties. The RTDs of both materials were examined in two differently scaled rotary tablet presses and the influence of process parameters was determined. To analyze RTDs independent of the mass flow, the normalized variance was used to quantify intermixing. Substantial differences between both materials and tablet presses were found. Broader RTDs were measured for the poorer flowing MCC as well as for the production scale press. The obtained results can be used to improve the general understanding of powder flow inside rotary tablet presses and amplify scale-up and continuous production process development. View Full-Text
Keywords: tableting; powder flow; feed frame; scale-up; intermixing tableting; powder flow; feed frame; scale-up; intermixing
Show Figures

Figure 1

MDPI and ACS Style

Puckhaber, D.; Eichler, S.; Kwade, A.; Finke, J.H. Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical Excipients in Rotary Tablet Presses. Pharmaceutics 2020, 12, 283.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop