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Open AccessArticle

Sulforaphane-Loaded Ultradeformable Vesicles as A Potential Natural Nanomedicine for the Treatment of Skin Cancer Diseases

1
Department of Experimental and Clinical Medicine, University “Magna Græcia” of Catanzaro, Campus Universitario “S. Venuta”, viale Europa, 88100 Catanzaro, Italy
2
Department of Experimental Medicine, University of Perugia, Piazzale Lucio Severi n. 1, 06132 Perugia, Italy
3
Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario “S. Venuta”, viale Europa, 88100 Catanzaro, Italy
4
Pincer Training and Research Institute, Plot 1127, Lukuli Zone 5 00256, Uganda
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(1), 6; https://doi.org/10.3390/pharmaceutics12010006
Received: 13 November 2019 / Revised: 9 December 2019 / Accepted: 17 December 2019 / Published: 19 December 2019
(This article belongs to the Special Issue Emergent Strategies for Natural Products Delivery)
Sulforaphane is a multi-action drug and its anticancer activity is the reason for the continuous growth of attention being paid to this drug. Sulforaphane shows an in vitro antiproliferative activity against melanoma and other skin cancer diseases. Unfortunately, this natural compound cannot be applied in free form on the skin due to its poor percutaneous permeation determined by its physico-chemical characteristics. The aim of this investigation was to evaluate ethosomes® and transfersomes® as ultradeformable vesicular carriers for the percutaneous delivery of sulforaphane to be used for the treatment of skin cancer diseases. The physico-chemical features of the ultradeformable vesicles were evaluated. Namely, ethosomes® and transfersomes® had mean sizes <400 nm and a polydispersity index close to 0. The stability studies demonstrated that the most suitable ultradeformable vesicles to be used as topical carriers of sulforaphane were ethosomes® made up of ethanol 40% (w/v) and phospholipon 90G 2% (w/v). In particular, in vitro studies of percutaneous permeation through human stratum corneum and epidermis membranes showed an increase of the percutaneous permeation of sulforaphane. The antiproliferative activity of sulforaphane-loaded ethosomes® was tested on SK-MEL 28 and improved anticancer activity was observed in comparison with the free drug. View Full-Text
Keywords: sulphoraphane; ethosomes®; transfersomes®; human stratum corneum; percutaneous permeation; anticancer activity sulphoraphane; ethosomes®; transfersomes®; human stratum corneum; percutaneous permeation; anticancer activity
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MDPI and ACS Style

Cristiano, M.C.; Froiio, F.; Spaccapelo, R.; Mancuso, A.; Nisticò, S.P.; Udongo, B.P.; Fresta, M.; Paolino, D. Sulforaphane-Loaded Ultradeformable Vesicles as A Potential Natural Nanomedicine for the Treatment of Skin Cancer Diseases. Pharmaceutics 2020, 12, 6.

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