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Open AccessReview

Relating Advanced Electrospun Fiber Architectures to the Temporal Release of Active Agents to Meet the Needs of Next-Generation Intravaginal Delivery Applications

1
Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA
2
Center for Predictive Medicine, Louisville, KY 40202, USA
3
Department of Chemical Engineering, University of Louisville, Louisville, KY 40292, USA
4
Department of Biology, University of Louisville, Louisville, KY 40292, USA
5
Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY 40292, USA
6
Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
*
Author to whom correspondence should be addressed.
Co-first authors.
Pharmaceutics 2019, 11(4), 160; https://doi.org/10.3390/pharmaceutics11040160
Received: 7 March 2019 / Revised: 28 March 2019 / Accepted: 30 March 2019 / Published: 3 April 2019
(This article belongs to the Special Issue Novel Approaches for Delivery of Anti-HIV Drugs)
Electrospun fibers have emerged as a relatively new delivery platform to improve active agent retention and delivery for intravaginal applications. While uniaxial fibers have been explored in a variety of applications including intravaginal delivery, the consideration of more advanced fiber architectures may offer new options to improve delivery to the female reproductive tract. In this review, we summarize the advancements of electrospun coaxial, multilayered, and nanoparticle-fiber architectures utilized in other applications and discuss how different material combinations within these architectures provide varied durations of release, here categorized as either transient (within 24 h), short-term (24 h to one week), or sustained (beyond one week). We seek to systematically relate material type and fiber architecture to active agent release kinetics. Last, we explore how lessons derived from these architectures may be applied to address the needs of future intravaginal delivery platforms for a given prophylactic or therapeutic application. The overall goal of this review is to provide a summary of different fiber architectures that have been useful for active agent delivery and to provide guidelines for the development of new formulations that exhibit release kinetics relevant to the time frames and the diversity of active agents needed in next-generation multipurpose applications. View Full-Text
Keywords: electrospun fibers; fiber architecture; drug delivery; intravaginal delivery; delivery vehicle electrospun fibers; fiber architecture; drug delivery; intravaginal delivery; delivery vehicle
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MDPI and ACS Style

Tyo, K.M.; Minooei, F.; Curry, K.C.; NeCamp, S.M.; Graves, D.L.; Fried, J.R.; Steinbach-Rankins, J.M. Relating Advanced Electrospun Fiber Architectures to the Temporal Release of Active Agents to Meet the Needs of Next-Generation Intravaginal Delivery Applications. Pharmaceutics 2019, 11, 160.

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