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Review

Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights

1
Museum of Literature in Moravia, Klášter 1, 664 61 Rajhrad, Czech Republic
2
Department of Applied Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Prague, Czech Republic
3
Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia
4
Department of Food Technology, University Center Koprivnica, University North, Trga Dr. Žarka Dolinara 1, 48 000 Koprivnica, Croatia
5
Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia
*
Author to whom correspondence should be addressed.
Academic Editor: Tomas Ruml
Viruses 2022, 14(3), 592; https://doi.org/10.3390/v14030592
Received: 30 December 2021 / Revised: 8 March 2022 / Accepted: 11 March 2022 / Published: 13 March 2022
Human herpesviruses (HHVs) are large DNA viruses with highly infectious characteristics. HHVs can induce lytic and latent infections in their host, and most of these viruses are neurotropic, with the capacity to generate severe and chronic neurological diseases of the peripheral nervous system (PNS) and central nervous system (CNS). Treatment of HHV infections based on strategies that include natural products-derived drugs is one of the most rapidly developing fields of modern medicine. Therefore, in this paper, we lend insights into the recent advances that have been achieved during the past five years in utilizing flavonoids as promising natural drugs for the treatment of HHVs infections of the nervous system such as alpha-herpesviruses (herpes simplex virus type 1, type 2, and varicella-zoster virus), beta-herpesviruses (human cytomegalovirus), and gamma-herpesviruses (Epstein–Barr virus and Kaposi sarcoma-associated herpesvirus). The neurological complications associated with infections induced by the reviewed herpesviruses are emphasized. Additionally, this work covers all possible mechanisms and pathways by which flavonoids induce promising therapeutic actions against the above-mentioned herpesviruses. View Full-Text
Keywords: flavonoids; herpes simplex virus; HSV-1; HSV-2; varicella-zoster virus; Epstein–Barr virus; human cytomegalovirus; Kaposi sarcoma-associated herpesvirus; mechanisms of action; nervous system; neurological diseases flavonoids; herpes simplex virus; HSV-1; HSV-2; varicella-zoster virus; Epstein–Barr virus; human cytomegalovirus; Kaposi sarcoma-associated herpesvirus; mechanisms of action; nervous system; neurological diseases
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MDPI and ACS Style

Šudomová, M.; Berchová-Bímová, K.; Mazurakova, A.; Šamec, D.; Kubatka, P.; Hassan, S.T.S. Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights. Viruses 2022, 14, 592. https://doi.org/10.3390/v14030592

AMA Style

Šudomová M, Berchová-Bímová K, Mazurakova A, Šamec D, Kubatka P, Hassan STS. Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights. Viruses. 2022; 14(3):592. https://doi.org/10.3390/v14030592

Chicago/Turabian Style

Šudomová, Miroslava, Kateřina Berchová-Bímová, Alena Mazurakova, Dunja Šamec, Peter Kubatka, and Sherif T. S. Hassan. 2022. "Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights" Viruses 14, no. 3: 592. https://doi.org/10.3390/v14030592

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