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Article

The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral Defense

Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, Turkey
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Author to whom correspondence should be addressed.
Academic Editors: Concetta Castilletti, Luisa Barzon and Francesca Colavita
Viruses 2021, 13(3), 394; https://doi.org/10.3390/v13030394
Received: 3 February 2021 / Revised: 23 February 2021 / Accepted: 24 February 2021 / Published: 2 March 2021
(This article belongs to the Special Issue SARS-CoV-2 Host Cell Interactions)
Understanding SARS-CoV-2 evolution is a fundamental effort in coping with the COVID-19 pandemic. The virus genomes have been broadly evolving due to the high number of infected hosts world-wide. Mutagenesis and selection are two inter-dependent mechanisms of virus diversification. However, which mechanisms contribute to the mutation profiles of SARS-CoV-2 remain under-explored. Here, we delineate the contribution of mutagenesis and selection to the genome diversity of SARS-CoV-2 isolates. We generated a comprehensive phylogenetic tree with representative genomes. Instead of counting mutations relative to the reference genome, we identified each mutation event at the nodes of the phylogenetic tree. With this approach, we obtained the mutation events that are independent of each other and generated the mutation profile of SARS-CoV-2 genomes. The results suggest that the heterogeneous mutation patterns are mainly reflections of host (i) antiviral mechanisms that are achieved through APOBEC, ADAR, and ZAP proteins, and (ii) probable adaptation against reactive oxygen species. View Full-Text
Keywords: SARS-CoV-2; COVID-19; evolution; mutation; phylogenetics; APOBEC; ROS; ZAP; ADAR SARS-CoV-2; COVID-19; evolution; mutation; phylogenetics; APOBEC; ROS; ZAP; ADAR
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MDPI and ACS Style

Azgari, C.; Kilinc, Z.; Turhan, B.; Circi, D.; Adebali, O. The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral Defense. Viruses 2021, 13, 394. https://doi.org/10.3390/v13030394

AMA Style

Azgari C, Kilinc Z, Turhan B, Circi D, Adebali O. The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral Defense. Viruses. 2021; 13(3):394. https://doi.org/10.3390/v13030394

Chicago/Turabian Style

Azgari, Cem, Zeynep Kilinc, Berk Turhan, Defne Circi, and Ogun Adebali. 2021. "The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral Defense" Viruses 13, no. 3: 394. https://doi.org/10.3390/v13030394

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