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Open AccessArticle

Proteomics Computational Analyses Suggest that the Antennavirus Glycoprotein Complex Includes a Class I Viral Fusion Protein (α-Penetrene) with an Internal Zinc-Binding Domain and a Stable Signal Peptide

1
School of Nursing, Johns Hopkins University, Baltimore, MD 21205, USA
2
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA
3
Zalgen Labs, Germantown, MD 20876, USA
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(8), 750; https://doi.org/10.3390/v11080750
Received: 20 July 2019 / Revised: 6 August 2019 / Accepted: 13 August 2019 / Published: 14 August 2019
(This article belongs to the Special Issue Emerging Viruses: Surveillance, Prevention, Evolution and Control)
A metatranscriptomic study of RNA viruses in cold-blooded vertebrates identified two related viruses from frogfish (Antennarius striatus) that represent a new genus Antennavirus in the family Arenaviridae (Order: Bunyavirales). Computational analyses were used to identify features common to class I viral fusion proteins (VFPs) in antennavirus glycoproteins, including an N-terminal fusion peptide, two extended alpha-helices, an intrahelical loop, and a carboxyl terminal transmembrane domain. Like mammarenavirus and hartmanivirus glycoproteins, the antennavirus glycoproteins have an intracellular zinc-binding domain and a long virion-associated stable signal peptide (SSP). The glycoproteins of reptarenaviruses are also class I VFPs, but do not contain zinc-binding domains nor do they encode SSPs. Divergent evolution from a common progenitor potentially explains similarities of antennavirus, mammarenavirus, and hartmanivirus glycoproteins, with an ancient recombination event resulting in a divergent reptarenavirus glycoprotein. View Full-Text
Keywords: arenavirus glycoproteins; antennavirus; mammarenavirus; hartmanivirus; reptarenavirus; class I viral fusion protein; internal zinc-binding domain; stable signal peptide arenavirus glycoproteins; antennavirus; mammarenavirus; hartmanivirus; reptarenavirus; class I viral fusion protein; internal zinc-binding domain; stable signal peptide
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MDPI and ACS Style

Garry, C.E.; Garry, R.F. Proteomics Computational Analyses Suggest that the Antennavirus Glycoprotein Complex Includes a Class I Viral Fusion Protein (α-Penetrene) with an Internal Zinc-Binding Domain and a Stable Signal Peptide. Viruses 2019, 11, 750. https://doi.org/10.3390/v11080750

AMA Style

Garry CE, Garry RF. Proteomics Computational Analyses Suggest that the Antennavirus Glycoprotein Complex Includes a Class I Viral Fusion Protein (α-Penetrene) with an Internal Zinc-Binding Domain and a Stable Signal Peptide. Viruses. 2019; 11(8):750. https://doi.org/10.3390/v11080750

Chicago/Turabian Style

Garry, Courtney E.; Garry, Robert F. 2019. "Proteomics Computational Analyses Suggest that the Antennavirus Glycoprotein Complex Includes a Class I Viral Fusion Protein (α-Penetrene) with an Internal Zinc-Binding Domain and a Stable Signal Peptide" Viruses 11, no. 8: 750. https://doi.org/10.3390/v11080750

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