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Trans-Acting RNA–RNA Interactions in Segmented RNA Viruses

Department of Biology, York University, Toronto, ON M3J 1P3, Canada
Author to whom correspondence should be addressed.
Viruses 2019, 11(8), 751;
Received: 18 July 2019 / Revised: 8 August 2019 / Accepted: 11 August 2019 / Published: 14 August 2019
(This article belongs to the Special Issue Viruses Ten-Year Anniversary)
PDF [1545 KB, uploaded 14 August 2019]


RNA viruses represent a large and important group of pathogens that infect a broad range of hosts. Segmented RNA viruses are a subclass of this group that encode their genomes in two or more molecules and package all of their RNA segments in a single virus particle. These divided genomes come in different forms, including double-stranded RNA, coding-sense single-stranded RNA, and noncoding single-stranded RNA. Genera that possess these genome types include, respectively, Orbivirus (e.g., Bluetongue virus), Dianthovirus (e.g., Red clover necrotic mosaic virus) and Alphainfluenzavirus (e.g., Influenza A virus). Despite their distinct genomic features and diverse host ranges (i.e., animals, plants, and humans, respectively) each of these viruses uses trans-acting RNA–RNA interactions (tRRIs) to facilitate co-packaging of their segmented genome. The tRRIs occur between different viral genome segments and direct the selective packaging of a complete genome complement. Here we explore the current state of understanding of tRRI-mediated co-packaging in the abovementioned viruses and examine other known and potential functions for this class of RNA–RNA interaction. View Full-Text
Keywords: RNA structure; RNA–RNA interactions; RNA virus; RNA packaging; segmented virus; influenza virus; bluetongue virus; reovirus; red clover necrotic mosaic virus RNA structure; RNA–RNA interactions; RNA virus; RNA packaging; segmented virus; influenza virus; bluetongue virus; reovirus; red clover necrotic mosaic virus

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Newburn, L.R.; White, K.A. Trans-Acting RNA–RNA Interactions in Segmented RNA Viruses. Viruses 2019, 11, 751.

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