Trans-Acting RNA–RNA Interactions in Segmented RNA Viruses
AbstractRNA viruses represent a large and important group of pathogens that infect a broad range of hosts. Segmented RNA viruses are a subclass of this group that encode their genomes in two or more molecules and package all of their RNA segments in a single virus particle. These divided genomes come in different forms, including double-stranded RNA, coding-sense single-stranded RNA, and noncoding single-stranded RNA. Genera that possess these genome types include, respectively, Orbivirus (e.g., Bluetongue virus), Dianthovirus (e.g., Red clover necrotic mosaic virus) and Alphainfluenzavirus (e.g., Influenza A virus). Despite their distinct genomic features and diverse host ranges (i.e., animals, plants, and humans, respectively) each of these viruses uses trans-acting RNA–RNA interactions (tRRIs) to facilitate co-packaging of their segmented genome. The tRRIs occur between different viral genome segments and direct the selective packaging of a complete genome complement. Here we explore the current state of understanding of tRRI-mediated co-packaging in the abovementioned viruses and examine other known and potential functions for this class of RNA–RNA interaction. View Full-Text
Share & Cite This Article
Newburn, L.R.; White, K.A. Trans-Acting RNA–RNA Interactions in Segmented RNA Viruses. Viruses 2019, 11, 751.
Newburn LR, White KA. Trans-Acting RNA–RNA Interactions in Segmented RNA Viruses. Viruses. 2019; 11(8):751.Chicago/Turabian Style
Newburn, Laura R.; White, K. A. 2019. "Trans-Acting RNA–RNA Interactions in Segmented RNA Viruses." Viruses 11, no. 8: 751.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.