Next Article in Journal
Evidence of Intragenic Recombination in African Horse Sickness Virus
Next Article in Special Issue
Genetic Markers Associated with Field PRRSV-Induced Abortion Rates
Previous Article in Journal
Wild Rats, Laboratory Rats, Pet Rats: Global Seoul Hantavirus Disease Revisited
Previous Article in Special Issue
Differential Effect of the Deletion of African Swine Fever Virus Virulence-Associated Genes in the Induction of Attenuation of the Highly Virulent Georgia Strain
Article

Long-Term Circulation of Atypical Porcine Pestivirus (APPV) within Switzerland

1
Institute of Virology and Immunology (IVI), 3001 Bern and 3147 Mittelhäusern, Switzerland
2
Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland
3
Division of Swine Medicine, Department for Farm Animals, Vetsuisse Faculty, University of Zürich, 8057 Zürich, Switzerland
4
Institute of Animal Pathology, 3001 Bern, Switzerland
5
Clinic for Swine, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland
*
Author to whom correspondence should be addressed.
Current address: Animal Physiology, Department of Environmental Systems Science, ETH Zurich, 8092 Zürich, Switzerland.
Viruses 2019, 11(7), 653; https://doi.org/10.3390/v11070653
Received: 3 July 2019 / Revised: 12 July 2019 / Accepted: 16 July 2019 / Published: 17 July 2019
(This article belongs to the Special Issue Porcine Viruses 2019)
In 2015, a new pestivirus was described in pig sera in the United States. This new “atypical porcine pestivirus” (APPV) was later associated with congenital tremor (CT) in newborn piglets. The virus appears to be distributed worldwide, but the limited knowledge of virus diversity and the use of various diagnostic tests prevent direct comparisons. Therefore, we developed an APPV-specific real-time RT-PCR assay in the 5′UTR of the viral genome to investigate both retro- and prospectively the strains present in Switzerland and their prevalence in domestic pigs. Overall, 1080 sera obtained between 1986 and 2018 were analyzed, revealing a virus prevalence of approximately 13% in pigs for slaughter, whereas it was less than 1% in breeding pigs. In the prospective study, APPV was also detected in piglets displaying CT. None of the samples could detect the Linda virus, which is another new pestivirus recently reported in Austria. Sequencing and phylogenetic analysis revealed a broad diversity of APP viruses in Switzerland that are considerably distinct from sequences reported from other isolates in Europe and overseas. This study indicates that APPV has already been widely circulating in Switzerland for many years, mainly in young animals, with 1986 being the earliest report of APPV worldwide. View Full-Text
Keywords: atypical porcine pestivirus; APPV; epidemiology; prevalence; Switzerland; real-time RT-PCR; phylogenetic analysis; congenital tremor atypical porcine pestivirus; APPV; epidemiology; prevalence; Switzerland; real-time RT-PCR; phylogenetic analysis; congenital tremor
Show Figures

Figure 1

MDPI and ACS Style

Kaufmann, C.; Stalder, H.; Sidler, X.; Renzullo, S.; Gurtner, C.; Grahofer, A.; Schweizer, M. Long-Term Circulation of Atypical Porcine Pestivirus (APPV) within Switzerland. Viruses 2019, 11, 653. https://doi.org/10.3390/v11070653

AMA Style

Kaufmann C, Stalder H, Sidler X, Renzullo S, Gurtner C, Grahofer A, Schweizer M. Long-Term Circulation of Atypical Porcine Pestivirus (APPV) within Switzerland. Viruses. 2019; 11(7):653. https://doi.org/10.3390/v11070653

Chicago/Turabian Style

Kaufmann, Cindy; Stalder, Hanspeter; Sidler, Xaver; Renzullo, Sandra; Gurtner, Corinne; Grahofer, Alexander; Schweizer, Matthias. 2019. "Long-Term Circulation of Atypical Porcine Pestivirus (APPV) within Switzerland" Viruses 11, no. 7: 653. https://doi.org/10.3390/v11070653

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop