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Overexpression of the Interferon-Inducible Isoform 4 of NCOA7 Dissects the Entry Route of Enveloped Viruses and Demonstrates that HIV Enters Cells via Fusion at the Plasma Membrane

1
Childhood Cancer Research Unit, Department of Women’s and Children’s Health, Karolinska Institutet, 171 76 Stockholm, Sweden
2
Paediatric Oncology, Theme Women’s and Children’s Health, Karolinska University Hospital, 171 76 Stockholm, Sweden
Viruses 2019, 11(2), 121; https://doi.org/10.3390/v11020121
Received: 20 January 2019 / Revised: 24 January 2019 / Accepted: 27 January 2019 / Published: 29 January 2019
(This article belongs to the Section Animal Viruses)
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PDF [195 KB, uploaded 29 January 2019]

Abstract

The HIV-1 entry-route is a matter of ongoing controversy, and there is evidence for fusion either at the cell surface or from within endosomes. A recent report demonstrated that isoform 4 of nuclear receptor coactivator 7 (NCOA7iso4) interacts with endolysosomal vacuolar-type H+-ATPase (V-ATPase), increasing lytic activity and thereby severely affecting the entry of vesicular stomatitis virus glycoprotein (VSV-G)-mediated, but not HIV-Env-mediated, entry and infection. As basal expression of NCOA7iso4 is low in the absence of type-1 interferons, its overexpression is a novel tool to study viral entry. View Full-Text
Keywords: human immunodeficiency virus; entry; endocytosis; fusion; NCOA7; VSV-G; Env; plasma membrane human immunodeficiency virus; entry; endocytosis; fusion; NCOA7; VSV-G; Env; plasma membrane
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Herold, N. Overexpression of the Interferon-Inducible Isoform 4 of NCOA7 Dissects the Entry Route of Enveloped Viruses and Demonstrates that HIV Enters Cells via Fusion at the Plasma Membrane. Viruses 2019, 11, 121.

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