Next Article in Journal
Chaperoning the Mononegavirales: Current Knowledge and Future Directions
Next Article in Special Issue
Tet-Inducible Production of Infectious Zika Virus from the Full-Length cDNA Clones of African- and Asian-Lineage Strains
Previous Article in Journal
Chrysoviruses in Magnaporthe oryzae
Previous Article in Special Issue
Characterizing the Different Effects of Zika Virus Infection in Placenta and Microglia Cells
Article Menu

Export Article

Open AccessArticle
Viruses 2018, 10(12), 698; https://doi.org/10.3390/v10120698

An Evolutionary Insight into Zika Virus Strains Isolated in the Latin American Region

1
Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo 11400, Uruguay
2
Laboratorio de Organización y Evolución del Genoma, Unidad de Genómica Evolutiva, Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo 11400, Uruguay
3
Laboratorio de Inmunovirología, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay
*
Authors to whom correspondence should be addressed.
Received: 30 September 2018 / Revised: 19 November 2018 / Accepted: 20 November 2018 / Published: 8 December 2018
(This article belongs to the Special Issue New Advances on Zika Virus Research)
Full-Text   |   PDF [3246 KB, uploaded 8 December 2018]   |  

Abstract

Zika virus (ZIKV) is an emerging pathogen member of the Flaviviridae family. ZIKV has spread rapidly in the Latin American region, causing hundreds of thousands of cases of ZIKV disease, as well as microcephaly in congenital infections. Detailed studies on the pattern of evolution of ZIKV strains have been extremely important to our understanding of viral survival, fitness, and evasion of the host’s immune system. For these reasons, we performed a comprehensive phylogenetic analysis of ZIKV strains recently isolated in the Americas. The results of these studies revealed evidence of diversification of ZIKV strains circulating in the Latin American region into at least five different genetic clusters. This diversification was also reflected in the different trends in dinucleotide bias and codon usage variation. Amino acid substitutions were found in E and prM proteins of the ZIKV strains isolated in this region, revealing the presence of novel genetic variants circulating in Latin America. View Full-Text
Keywords: Zika; viral evolution; genetic variability; Bayesian analyses Zika; viral evolution; genetic variability; Bayesian analyses
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Simón, D.; Fajardo, A.; Moreno, P.; Moratorio, G.; Cristina, J. An Evolutionary Insight into Zika Virus Strains Isolated in the Latin American Region. Viruses 2018, 10, 698.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top