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Viruses 2018, 10(12), 699; https://doi.org/10.3390/v10120699

Chaperoning the Mononegavirales: Current Knowledge and Future Directions

Institute for Integrative Systems Biology (I2SysBio), Universitat de Valencia-CSIC, 46980 Valencia, Spain
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Received: 16 November 2018 / Revised: 4 December 2018 / Accepted: 5 December 2018 / Published: 8 December 2018
(This article belongs to the Special Issue Breakthroughs in Viral Replication)
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Abstract

The order Mononegavirales harbors numerous viruses of significant relevance to human health, including both established and emerging infections. Currently, vaccines are only available for a small subset of these viruses, and antiviral therapies remain limited. Being obligate cellular parasites, viruses must utilize the cellular machinery for their replication and spread. Therefore, targeting cellular pathways used by viruses can provide novel therapeutic approaches. One of the key challenges confronted by both hosts and viruses alike is the successful folding and maturation of proteins. In cells, this task is faced by cellular molecular chaperones, a group of conserved and abundant proteins that oversee protein folding and help maintain protein homeostasis. In this review, we summarize the current knowledge of how the Mononegavirales interact with cellular chaperones, highlight key gaps in our knowledge, and discuss the potential of chaperone inhibitors as antivirals. View Full-Text
Keywords: Mononegavirales; chaperones; antivirals; Hsp70; Hsp90; CCT; respiratory syncytial virus; measles virus; mumps virus; rabies virus; Ebola virus Mononegavirales; chaperones; antivirals; Hsp70; Hsp90; CCT; respiratory syncytial virus; measles virus; mumps virus; rabies virus; Ebola virus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Latorre, V.; Mattenberger, F.; Geller, R. Chaperoning the Mononegavirales: Current Knowledge and Future Directions. Viruses 2018, 10, 699.

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