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Article

Refractory Metal Coated Alumina Foams as Support Material for Stem Cell and Fibroblasts Cultivation

1
Institute of Materials and Joining Technology, Otto-von-Guericke-University Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany
2
Institute of Chemistry—Core Facility Tissue Engineering, Otto-von-Guericke-University Magdeburg, Pfaelzerstr. 2, 39106 Magdeburg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Roman Perez Antoñanzas
Materials 2021, 14(11), 2813; https://doi.org/10.3390/ma14112813
Received: 30 March 2021 / Revised: 16 May 2021 / Accepted: 21 May 2021 / Published: 25 May 2021
(This article belongs to the Special Issue Advances in Functional Cellular Structures and Composites)
Ceramics are widely used as implant materials; however, they are brittle and may emit particles when used in these applications. To overcome this disadvantage, alumina foams, which represent a 3D cellular structure comparable to that of human trabecular bone structures, were sputter coated with platinum, tantalum or titanium and modified with fibronectin or collagen type I, components of the extracellular matrix (ECM). To proof the cell material interaction, the unmodified and modified materials were cultured with (a) mesenchymal stem cells being a perfect indicator for biocompatibility and releasing important cytokines of the stem cell niche and (b) with fibroblasts characterized as mediators of inflammation and therefore an important cellular component of the foreign body reaction and inflammation after implantation. To optimize and compare the influence of metal surfaces on cellular behavior, planar glass substrates have been used. Identified biocompatible metal surface of platinum, titanium and tantalum were sputtered on ceramic foams modified with the above-mentioned ECM components to investigate cellular behavior in a 3D environment. The cellular alumina support was characterized with respect to its cellular/porous structure and niche accessibility and coating thickness of the refractory metals; the average cell size was 2.3 mm, the average size of the cell windows was 1.8 mm, and the total foam porosity was 91.4%. The Pt, Ti and Ta coatings were completely dense covering the entire alumina foam surface. The metals titanium and tantalum were colonized very well by the stem cells without a coating of ECM components, whereas the fibroblasts preferred components of the ECM on the alumina foam surface. View Full-Text
Keywords: ceramic foams; metal coating; biomaterials; tissue engineering; stem cell cultivation ceramic foams; metal coating; biomaterials; tissue engineering; stem cell cultivation
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MDPI and ACS Style

Hasemann, G.; Betke, U.; Krüger, M.; Walles, H.; Scheffler, M. Refractory Metal Coated Alumina Foams as Support Material for Stem Cell and Fibroblasts Cultivation. Materials 2021, 14, 2813. https://doi.org/10.3390/ma14112813

AMA Style

Hasemann G, Betke U, Krüger M, Walles H, Scheffler M. Refractory Metal Coated Alumina Foams as Support Material for Stem Cell and Fibroblasts Cultivation. Materials. 2021; 14(11):2813. https://doi.org/10.3390/ma14112813

Chicago/Turabian Style

Hasemann, Georg, Ulf Betke, Manja Krüger, Heike Walles, and Michael Scheffler. 2021. "Refractory Metal Coated Alumina Foams as Support Material for Stem Cell and Fibroblasts Cultivation" Materials 14, no. 11: 2813. https://doi.org/10.3390/ma14112813

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