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Neutralized Dicalcium Phosphate and Hydroxyapatite Biphasic Bioceramics Promote Bone Regeneration in Critical Peri-Implant Bone Defects

1
Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei 10048, Taiwan
2
Department of Dentistry, National Taiwan University Hospital, Taipei 10048, Taiwan
3
Department of Dentistry, Cardinal Tien Hospital Yonghe Branch, New Taipei City 23445, Taiwan
*
Author to whom correspondence should be addressed.
Materials 2020, 13(4), 823; https://doi.org/10.3390/ma13040823 (registering DOI)
Received: 24 December 2019 / Revised: 10 February 2020 / Accepted: 10 February 2020 / Published: 11 February 2020
The aim of this study was to evaluate the efficacy of bone regeneration in developed bioceramics composed of dicalcium phosphate and hydroxyapatite (DCP/HA). Critical bony defects were prepared in mandibles of beagles. Defects were grafted using DCP/HA or collagen-enhanced particulate biphasic calcium phosphate (TCP/HA/Col), in addition to a control group without grafting. To assess the efficacy of new bone formation, implant stability quotient (ISQ) values, serial bone labeling, and radiographic and histological percentage of marginal bone coverage (PMBC) were carefully evaluated four, eight, and 12 weeks after surgery. Statistically significant differences among the groups were observed in the histological PMBC after four weeks. The DCP/HA group consistently exhibited significantly higher ISQ values and radiographic and histological PMCB eight and 12 weeks after surgery. At 12 weeks, the histological PMBC of DCP/HA (72.25% ± 2.99%) was higher than that in the TCP/HA/Col (62.61% ± 1.52%) and control groups (30.64% ± 2.57%). After rigorously evaluating the healing of biphasic DCP/HA bioceramics with a critical size peri-implant model with serial bone labeling, we confirmed that neutralized bioceramics exhibiting optimal compression strength and biphasic properties show promising efficacy in fast bone formation and high marginal bone coverage in peri-implant bone defects. View Full-Text
Keywords: animal experiments; biomaterials; bone implant interactions; bone substitutes; guided tissue regeneration; bone regeneration; wound healing animal experiments; biomaterials; bone implant interactions; bone substitutes; guided tissue regeneration; bone regeneration; wound healing
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Chang, H.-H.; Yeh, C.-L.; Wang, Y.-L.; Fu, K.-K.; Tsai, S.-J.; Yang, J.-H.; Lin, C.-P. Neutralized Dicalcium Phosphate and Hydroxyapatite Biphasic Bioceramics Promote Bone Regeneration in Critical Peri-Implant Bone Defects. Materials 2020, 13, 823.

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