Next Article in Journal
Determination of Displacement Fields at the Sub-Nanometric Scale
Next Article in Special Issue
Preparation and Characterization of Natural Bleaching Gels Used in Cosmetic Dentistry
Previous Article in Journal
Aggregation of Gold Nanoparticles Caused in Two Different Ways Involved in 4-Mercaptophenylboronic Acidand Hydrogen Peroxide
Open AccessArticle

Metal Ion-Chelated Tannic Acid Coating for Hemostatic Dressing

Liaoning Key Laboratory of Molecular Recognition and Imaging, School of Bioengineering, Dalian University of Technology, Dalian 116023, China
Author to whom correspondence should be addressed.
Materials 2019, 12(11), 1803;
Received: 25 April 2019 / Revised: 27 May 2019 / Accepted: 29 May 2019 / Published: 3 June 2019
PDF [1995 KB, uploaded 3 June 2019]
  |     |  


Tannic acid (TA), a high-molecular-weight polyphenol, is used as a hemostasis spray and unguent for trauma wound remedy in traditional medical treatment. However, the use of tannic acid on a large-area wound would lead to absorption poisoning. In this work, a TA coating was assembled on a quartz/silicon slide, or medical gauze, via chelation interaction between TA and Fe3+ ions and for further use as a hemostasis dressing. Protein adsorption on the TA coating was further investigated by fluorescence signal, ellipsometry analysis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The adsorbed bovine serum albumin (BSA), immunoglobulin G (IgG) and fibrinogen (Fgn) on the TA coating was in the manner of monolayer saturation adsorption, and fibrinogen showed the largest adsorption. Furthermore, we found the slight hemolysis of the TA coating caused by the lysed red blood cells and adsorption of protein, especially the clotting-related fibrinogen, resulted in excellent hemostasis performance of the TA coating in the blood clotting of an animal wound. Thus, this economic, environmentally friendly, flexible TA coating has potential in medical applications as a means of preparing novel hemostasis materials. View Full-Text
Keywords: tannic acid; surface coating; protein adsorption; hemostatic dressing tannic acid; surface coating; protein adsorption; hemostatic dressing

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Song, B.; Yang, L.; Han, L.; Jia, L. Metal Ion-Chelated Tannic Acid Coating for Hemostatic Dressing. Materials 2019, 12, 1803.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top