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Open AccessFeature PaperArticle

Sol–Gel Synthesis of Silica-Based Materials with Different Percentages of PEG or PCL and High Chlorogenic Acid Content

1
Department of Engineering, University of Campania “Luigi Vanvitelli”, via Roma 29, 81031 Aversa, Italy
2
Ecoricerche srl, via Principi Normanni 36, 81043 Capua Caserta, Italy
3
Department of Civil Engineering and Architecture and UdR-Catania Consorzio INSTM, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
*
Author to whom correspondence should be addressed.
Materials 2019, 12(1), 155; https://doi.org/10.3390/ma12010155
Received: 10 December 2018 / Revised: 23 December 2018 / Accepted: 29 December 2018 / Published: 6 January 2019
(This article belongs to the Special Issue Biomaterials Synthesized via Sol–Gel Methods)
Implanted biomedical devices can induce adverse responses in the human body, which can cause failure of the implant—referred to as implant failure. Early implant failure is induced numerous factors, most importantly, infection and inflammation. Natural products are, today, one of the main sources of new drug molecules due to the development of pathogenic bacterial strains that possess resistance to more antibiotics used currently in various diseases. The aim of this work is the sol–gel synthesis of antibacterial biomedical implants. In the silica matrix, different percentages (6, 12, 24, 50 wt %) of polyethylene glycol (PEG) or poly(ε-caprolactone) (PCL) were embedded. Subsequently, the ethanol solutions with high amounts of chlorogenic acid (CGA 20 wt %) were slowly added to SiO2/PEG and SiO2/PCL sol. The interactions among different organic and inorganic phases in the hybrid materials was studied by Fourier transform infrared (FTIR) spectroscopy. Furthermore, the materials were soaked in simulated body fluid (SBF) for 21 days and the formation of a hydroxyapatite layer on their surface was evaluated by FTIR and XRD analysis. Finally, Escherichia coli and Pseudomonas aeruginosa were incubated with several hybrids, and the diameter of zone of inhibition was observed to assessment the potential antibacterial properties of the hybrids. View Full-Text
Keywords: sol–gel method; hybrid materials; antibacterial activity; chlorogenic acid; PEG; PCL; biomaterials sol–gel method; hybrid materials; antibacterial activity; chlorogenic acid; PEG; PCL; biomaterials
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Tranquillo, E.; Barrino, F.; Dal Poggetto, G.; Blanco, I. Sol–Gel Synthesis of Silica-Based Materials with Different Percentages of PEG or PCL and High Chlorogenic Acid Content. Materials 2019, 12, 155.

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