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Pathophysiology, Volume 32, Issue 2

June 2025 - 16 articles

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Articles (16)

  • Communication
  • Open Access
546 Views
9 Pages

Reduced Shear Stress and Longer Blood Flow Time Occur in Both Severe Focal and Mild Diffuse LAD Lesions: Angiograms Alone Don’t Always Reveal Their True Impact on Blood Flow

  • Gianluca Rigatelli,
  • Marco Zuin,
  • Niva Mileva,
  • Dobrin Vassilev,
  • Giuseppe Marchese,
  • Ervis Hiso,
  • Andrea Bertolini and
  • Claudio Bilato

Background/Objectives: The similarities and differences from a rheological perspective between significant short focal and mild long coronary lesions warrant investigation to elucidate wall shear stress (WSS) angiographic discrepancies. Methods: Pati...

  • Article
  • Open Access
2 Citations
1,118 Views
31 Pages

A Slow Hydrogen Sulfide Donor GYY-4137 Partially Improves Vascular Function in Spontaneously Hypertensive Rats Fed a High-Fat Diet

  • Basak G. Aydemir,
  • Andrea Berenyiova,
  • Martina Cebova,
  • John D. Henderson,
  • Andrej Barta and
  • Sona Cacanyiova

Background/Objectives: Metabolic syndrome is one of the leading causes of mortality worldwide, with high-fat diet (HFD) intake being a significant driving force. Despite long-term research, new interventions are still being sought to improve cardiova...

  • Review
  • Open Access
3 Citations
2,966 Views
35 Pages

Lipids play important roles in maintaining pulmonary structure, performing physiological functions and controlling the immune status of the lung. There is increasing evidence that lipid metabolism and immune activity are closely linked and that dysfu...

  • Case Report
  • Open Access
1,078 Views
5 Pages

A four-year-old female patient was admitted for evaluation after a mass on the right side of her neck was noticed during straining (Valsalva maneuver). The family first observed the mass when the patient was one year old, and noted that it gradually...

  • Article
  • Open Access
1,234 Views
18 Pages

Histochemical Assessment of Reticulin–Collagen Patterns in the Mid-Secretory Endometrium Predicts Recurrent Pregnancy Loss

  • Nazerke Oshakhtiyeva,
  • Dmitriy Klyuyev,
  • Zhanna Amirbekova,
  • Rinat Gatin,
  • Anar Turmukhambetova,
  • Kamilya Makhambetova,
  • Irina Kadyrova and
  • Yevgeniy Kamyshanskiy

Background/Objectives: Normal remodeling of the extracellular matrix of the endometrium is a necessary condition for the implantation of a blastocyst. We evaluated whether the use of histochemical reticulin–collagen staining can improve the ass...

  • Article
  • Open Access
1 Citations
1,069 Views
14 Pages

Elevated Zinc and Potassium Levels in Renal Calculi Indicate Distinct Pathophysiological Mechanisms in Urolithiasis

  • Maciej Jaromin,
  • Marcin Cichocki,
  • Tomasz Konecki,
  • Piotr Kutwin,
  • Waldemar Maniukiewicz,
  • Piotr Wysocki,
  • Magdalena Gajek,
  • Małgorzata Iwona Szynkowska-Jóźwik and
  • Dariusz Moczulski

Background/Objectives: Urolithiasis is a common disease in Western societies, affecting approximately 10% of the population, and more often men than women. The formation of renal calculi is a complex process, including various compounds and proteins....

  • Case Report
  • Open Access
1 Citations
1,603 Views
16 Pages

Fibrillary Glomerulonephritis Diagnosis Is Enhanced by DNAJB9: Three Cases with Different Clinical, Anatomopathologic Features and Outcomes

  • José C. De La Flor,
  • Marco Dominguez Davalos,
  • Tania Linares Grávalos,
  • Marina Alonso-Riaño,
  • Francisco Díaz,
  • Celia Rodríguez Tudero,
  • Rocío Zamora González-Mariño,
  • Michael Cieza Terrones and
  • Jesús Hernández Vaquero

Background: Fibrillary glomerulonephritis (FGN) is a rare and poorly understood kidney disease characterized by the deposition of non-amyloid fibrils in the glomeruli. Its clinical heterogeneity and high rate of progression to end-stage renal disease...

  • Article
  • Open Access
1 Citations
1,203 Views
13 Pages

Background/Objectives: The pathogenesis of intensive care unit-acquired weakness (ICU-AW) is multi-factorial, with some of the main risk factors being sepsis, multiorgan failure, and the inflammatory response related to critical illness. Vitamin D is...

  • Communication
  • Open Access
912 Views
9 Pages

Background/Objectives: This study explores variations in brain activity between individuals with dementia of the Alzheimer’s type (DAT) and healthy older adults during a resting state using functional near-infrared spectroscopy (fNIRS). Methods...

  • Article
  • Open Access
897 Views
12 Pages

Therapeutic Efficacy of Mesenchymal Stem Cells in Modulating Oxidative Stress in Puromycin-Induced Nephropathy

  • Yusuke Iizuka,
  • Masanori Sasaki,
  • Kojiro Terada,
  • Takuro Sakai,
  • Yoshinobu Nagaoka,
  • Shinobu Fukumura,
  • Jeffery D. Kocsis,
  • Takeshi Tsugawa and
  • Osamu Honmou

Background: Podocytes are essential for kidney function, and their dysfunction can result in nephrotic syndrome, such as minimal change disease (MCD). Oxidative stress contributes to podocyte damage. We investigated the therapeutic potential of intra...

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Pathophysiology - ISSN 1873-149X