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Current Oncology
Volume 29
Issue 5
10.3390/curroncol29050270
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Article

Using a Weekly Patient-Reported Outcome Questionnaire to Track Acute Toxicity in Patients Undergoing Pelvic Radiotherapy for Gynecologic Cancers

by
Matthew Chan
1,2,
Robert Olson
2,3,
Vincent Lapointe
1,
Jeremy Hamm
1,
Francois Bachand
2,4,
Caroline Holloway
2,5,
Christina Parsons
1,2 and
Peter Lim
1,2,*
1
BC Cancer–Vancouver, Vancouver, BC V6T 1Z4, Canada
2
Department of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
3
BC Cancer–Prince George, Prince George, BC V2M 7E9, Canada
4
BC Cancer–Kelowna, Kelowna, BC V1Y 5L3, Canada
5
BC Cancer–Victoria, Victoria, BC V8R 6V5, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2022, 29(5), 3306-3317; https://doi.org/10.3390/curroncol29050270
Received: 23 March 2022 / Revised: 28 April 2022 / Accepted: 3 May 2022 / Published: 5 May 2022
(This article belongs to the Special Issue Patient-Reported Outcome Use in Radiation Oncology Research and Routine Clinical Care)
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Abstract

There are limited patient-reported outcome (PRO) data tracking changes in toxicity in patients actively undergoing radiotherapy. Between 2015–2019, acute toxicity was prospectively measured in 698 patients undergoing a 5-week course of pelvic radiotherapy for gynecologic cancers using a weekly PRO questionnaire. Our questionnaire was able detect a pattern of onset and resolution of acute gastrointestinal (GI) and genitourinary (GU) toxicity in 27 out of 32 questions. Logistic regression analysis showed that increasing GI and GU toxicity at week 2 could predict for severe toxicity at week 5. However, due to a low number of severe events, univariate results could not be productively added to a multivariate model. We observed a >70% response rate for all sections of the questionnaire, except for questions on sexual and vaginal health, which had a 13% average response rate. By demonstrating that PRO data can be used to track acute toxicity during radiotherapy, there is a need to further examine how this tool may be implemented in the clinic to provide complex, adaptive care, such as early side effect management, and modifying radiation delivery in real-time. View Full-Text
Keywords: patient reported outcomes; acute toxicity; pelvic radiotherapy; gynecologic cancers patient reported outcomes; acute toxicity; pelvic radiotherapy; gynecologic cancers
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MDPI and ACS Style

Chan, M.; Olson, R.; Lapointe, V.; Hamm, J.; Bachand, F.; Holloway, C.; Parsons, C.; Lim, P. Using a Weekly Patient-Reported Outcome Questionnaire to Track Acute Toxicity in Patients Undergoing Pelvic Radiotherapy for Gynecologic Cancers. Curr. Oncol. 2022, 29, 3306-3317. https://doi.org/10.3390/curroncol29050270

AMA Style

Chan M, Olson R, Lapointe V, Hamm J, Bachand F, Holloway C, Parsons C, Lim P. Using a Weekly Patient-Reported Outcome Questionnaire to Track Acute Toxicity in Patients Undergoing Pelvic Radiotherapy for Gynecologic Cancers. Current Oncology. 2022; 29(5):3306-3317. https://doi.org/10.3390/curroncol29050270

Chicago/Turabian Style

Chan, Matthew, Robert Olson, Vincent Lapointe, Jeremy Hamm, Francois Bachand, Caroline Holloway, Christina Parsons, and Peter Lim. 2022. "Using a Weekly Patient-Reported Outcome Questionnaire to Track Acute Toxicity in Patients Undergoing Pelvic Radiotherapy for Gynecologic Cancers" Current Oncology 29, no. 5: 3306-3317. https://doi.org/10.3390/curroncol29050270

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