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Current Oncology
Volume 19
Issue 4
10.3747/co.19.983
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Case Report

Does Neurologic Deterioration Help to Differentiate between Pseudoprogression and True Disease Progression in Newly Diagnosed Glioblastoma Multiforme?

by
A.D. Singh
and
J.C. Easaw
*
Division of Neuro Oncology, Department of Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2012, 19(4), 295-298; https://doi.org/10.3747/co.19.983
Submission received: 2 May 2012 / Revised: 6 June 2012 / Accepted: 8 July 2012 / Published: 1 August 2012

Abstract

Enlarging or new lesions frequently appear on magnetic resonance imaging (mri) after concurrent administration of radiation therapy and temozolomide in glioblastoma multiforme (gbm) patients. However, in nearly half such cases, the observed radiologic changes are not due to true disease progression, but instead are a result of a post-radiation inflammatory state called “pseudoprogression.” Retrospective studies have reported that neurologic deterioration at the time of the post-chemoradiotherapy mri is found more commonly in patients with true disease progression. We report a gbm patient with both radiologic progression on the post-chemoradiotherapy mri and concomitant neurologic deterioration, and we caution against incorporating clinical deterioration into the management schema of patients with possible pseudoprogression.
Keywords: pseudoprogression; disease progression; neurologic deterioration; glioblastoma multiforme; mri; chemotherapy; radiation therapy; temozolomide pseudoprogression; disease progression; neurologic deterioration; glioblastoma multiforme; mri; chemotherapy; radiation therapy; temozolomide

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MDPI and ACS Style

Singh, A.D.; Easaw, J.C. Does Neurologic Deterioration Help to Differentiate between Pseudoprogression and True Disease Progression in Newly Diagnosed Glioblastoma Multiforme? Curr. Oncol. 2012, 19, 295-298. https://doi.org/10.3747/co.19.983

AMA Style

Singh AD, Easaw JC. Does Neurologic Deterioration Help to Differentiate between Pseudoprogression and True Disease Progression in Newly Diagnosed Glioblastoma Multiforme? Current Oncology. 2012; 19(4):295-298. https://doi.org/10.3747/co.19.983

Chicago/Turabian Style

Singh, A.D., and J.C. Easaw. 2012. "Does Neurologic Deterioration Help to Differentiate between Pseudoprogression and True Disease Progression in Newly Diagnosed Glioblastoma Multiforme?" Current Oncology 19, no. 4: 295-298. https://doi.org/10.3747/co.19.983

APA Style

Singh, A. D., & Easaw, J. C. (2012). Does Neurologic Deterioration Help to Differentiate between Pseudoprogression and True Disease Progression in Newly Diagnosed Glioblastoma Multiforme? Current Oncology, 19(4), 295-298. https://doi.org/10.3747/co.19.983

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