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Review

Novel Insights on the Role of Nitric Oxide in the Ovary: A Review of the Literature

1
Department of Medicine and Aging Sciences, University “G. d’Annunzio” Chieti-Pescara, Via Dei Vestini 31, 66100 Chieti, Italy
2
Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio” Chieti-Pescara, Via Dei Vestini 31, 66100 Chieti, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(3), 980; https://doi.org/10.3390/ijerph18030980
Received: 29 December 2020 / Revised: 18 January 2021 / Accepted: 20 January 2021 / Published: 22 January 2021
Nitric oxide (NO) is formed during the oxidation of L-arginine to L-citrulline by the action of multiple isoenzymes of NO synthase (NOS): neuronal NOS (nNOS), endotelial NOS (eNOS), and inducible NOS (iNOS). NO plays a relevant role in the vascular endothelium, in central and peripheral neurons, and in immunity and inflammatory systems. In addition, several authors showed a consistent contribution of NO to different aspects of the reproductive physiology. The aim of the present review is to analyse the published data on the role of NO within the ovary. It has been demonstrated that the multiple isoenzymes of NOS are expressed and localized in the ovary of different species. More to the point, a consistent role was ascribed to NO in the processes of steroidogenesis, folliculogenesis, and oocyte meiotic maturation in in vitro and in vivo studies using animal models. Unfortunately, there are few nitric oxide data for humans; there are preliminary data on the implication of nitric oxide for oocyte/embryo quality and in-vitro fertilization/embryo transfer (IVF/ET) parameters. NO plays a remarkable role in the ovary, but more investigation is needed, in particular in the context of human ovarian physiology. View Full-Text
Keywords: nitric oxide; folliculogenesis; steroidogenesis; meiotic maturation; in-vitro fertilization (IVF); embryo development nitric oxide; folliculogenesis; steroidogenesis; meiotic maturation; in-vitro fertilization (IVF); embryo development
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MDPI and ACS Style

Budani, M.C.; Tiboni, G.M. Novel Insights on the Role of Nitric Oxide in the Ovary: A Review of the Literature. Int. J. Environ. Res. Public Health 2021, 18, 980. https://doi.org/10.3390/ijerph18030980

AMA Style

Budani MC, Tiboni GM. Novel Insights on the Role of Nitric Oxide in the Ovary: A Review of the Literature. International Journal of Environmental Research and Public Health. 2021; 18(3):980. https://doi.org/10.3390/ijerph18030980

Chicago/Turabian Style

Budani, Maria Cristina, and Gian Mario Tiboni. 2021. "Novel Insights on the Role of Nitric Oxide in the Ovary: A Review of the Literature" International Journal of Environmental Research and Public Health 18, no. 3: 980. https://doi.org/10.3390/ijerph18030980

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