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Association between Pb, Cd, and Hg Exposure and Liver Injury among Korean Adults

1
Environmental Health Research Division, National institute of Environmental Research, Ministry of Environment, Incheon 22689, Korea
2
BK21 FOUR R & E Center for Learning Health System, Department of Health and Environmental Science, Korea University, Anam-ro 145, Seongbuk-gu, Seoul 02841, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(13), 6783; https://doi.org/10.3390/ijerph18136783
Received: 31 May 2021 / Revised: 20 June 2021 / Accepted: 21 June 2021 / Published: 24 June 2021
(This article belongs to the Section Environmental Health)
Background: Exposure to lead (Pb), cadmium (Cd), and mercury (Hg) has been reported to be associated with liver-related diseases. However, studies examining the association between heavy metal exposure and liver injury in a large population are scant and characterized by inconsistent results. This study aimed to evaluate the association between levels of heavy metal exposure and liver injury in the general population. Methods: Data for 2953 participants aged 19 years or more obtained from the Korean National Environmental Health Survey (KoNEHS) Cycle 3 (2015–2017) were used. The associations between levels of blood or urine heavy metals (Pb, Cd, and Hg) and liver function biomarkers [aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT)] were evaluated using multiple linear regression analysis. Results: Regarding the blood Pb (BPb), AST was higher in those of the 4th quartile, ALT was higher in those of the 2nd and 4th quartiles, and GGT was higher in those of the 3rd and 4th quartiles than in the 1st quartile. For urinary Cd (UCd), AST was higher in those of the 4th quartile; ALT was higher in those of the 2nd, 3rd, and 4th quartiles; and GGT was higher in the 4th quartile than in the 1st quartile. For the blood Hg (BHg), AST was higher in those of the 2nd and 4th quartile, ALT was higher in those of the 2nd, 3rd, and 4th quartiles; and GGT was higher in those of the 3rd and 4th quartiles than in the 1st quartile. There was no significant difference between urinary Hg (UHg) and liver function markers. Conclusion: Heavy metal exposure showed an association with liver injury among the general adult population in Korea. Further studies are required to clarify the relationship between heavy metals and liver injury. View Full-Text
Keywords: heavy metals; liver function; KoNEHS; epidemiology heavy metals; liver function; KoNEHS; epidemiology
MDPI and ACS Style

Kim, D.-W.; Ock, J.; Moon, K.-W.; Park, C.-H. Association between Pb, Cd, and Hg Exposure and Liver Injury among Korean Adults. Int. J. Environ. Res. Public Health 2021, 18, 6783. https://doi.org/10.3390/ijerph18136783

AMA Style

Kim D-W, Ock J, Moon K-W, Park C-H. Association between Pb, Cd, and Hg Exposure and Liver Injury among Korean Adults. International Journal of Environmental Research and Public Health. 2021; 18(13):6783. https://doi.org/10.3390/ijerph18136783

Chicago/Turabian Style

Kim, Do-Won, Jeongwon Ock, Kyong-Whan Moon, and Choong-Hee Park. 2021. "Association between Pb, Cd, and Hg Exposure and Liver Injury among Korean Adults" International Journal of Environmental Research and Public Health 18, no. 13: 6783. https://doi.org/10.3390/ijerph18136783

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