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Article

Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study

by
Jae Seung Chang
1,2,
Eunha Chang
1,2,
Yoonsuk Lee
3,
Yong Sung Cha
3,
Seung-Kuy Cha
1,2,
Won Gil Cho
1,4,
Yangsik Jeong
1,5,
Hyun Kim
3,* and
Kyu-Sang Park
1,2,*
1
Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
2
Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
3
Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
4
Department of Anatomy, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
5
Department of Biochemistry, Yonsei University Wonju College of Medicine, Wonju, Gangwon-Do 26426, Korea
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(21), 7853; https://doi.org/10.3390/ijerph17217853
Submission received: 28 August 2020 / Revised: 14 October 2020 / Accepted: 22 October 2020 / Published: 27 October 2020
(This article belongs to the Special Issue Environmental Physiology and Medicine: Diving and Hyperbaric Exposure)
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Abstract

Hyperbaric oxygen therapy (HBOT) has been used to provide oxygen to underperfused organs following ischemia or carbon monoxide intoxication. Various beneficial consequences of HBOT have been reported, including wound healing, anti-inflammatory action, and cell survival; however, the molecular mechanisms underlying these effects have not been elucidated yet. We applied a single HBOT program consisting of administration of 2.8 atmospheres absolute (ATA) for 45 min, followed by 2.0 ATA for 55 min, to 10 male volunteers without any metabolic disease. Within 1 week of HBOT, there was no alteration in serum biochemical variables, except for an increase in triglyceride content. As a mitochondrial stress indicator, the serum concentration of growth differentiation factor 15 was reduced by HBOT. The circulating level of γ–glutamyltransferase was also decreased by HBOT, suggesting an attenuation of oxidative stress. HBOT increased adiponectin and reduced leptin levels in the serum, leading to an elevated adiponectin/leptin ratio. This is the first study to investigate the effect of HBOT on serum levels of metabolic stress-related biomarkers. We suggest that HBOT attenuates mitochondrial and oxidative stresses, and relieves metabolic burdens, indicating its potential for use in therapeutic applications to metabolic diseases.
Keywords: hyperbaric oxygen therapy; biomarker; mitochondria; oxidative stress hyperbaric oxygen therapy; biomarker; mitochondria; oxidative stress

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MDPI and ACS Style

Chang, J.S.; Chang, E.; Lee, Y.; Cha, Y.S.; Cha, S.-K.; Cho, W.G.; Jeong, Y.; Kim, H.; Park, K.-S. Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study. Int. J. Environ. Res. Public Health 2020, 17, 7853. https://doi.org/10.3390/ijerph17217853

AMA Style

Chang JS, Chang E, Lee Y, Cha YS, Cha S-K, Cho WG, Jeong Y, Kim H, Park K-S. Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study. International Journal of Environmental Research and Public Health. 2020; 17(21):7853. https://doi.org/10.3390/ijerph17217853

Chicago/Turabian Style

Chang, Jae Seung, Eunha Chang, Yoonsuk Lee, Yong Sung Cha, Seung-Kuy Cha, Won Gil Cho, Yangsik Jeong, Hyun Kim, and Kyu-Sang Park. 2020. "Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study" International Journal of Environmental Research and Public Health 17, no. 21: 7853. https://doi.org/10.3390/ijerph17217853

APA Style

Chang, J. S., Chang, E., Lee, Y., Cha, Y. S., Cha, S.-K., Cho, W. G., Jeong, Y., Kim, H., & Park, K.-S. (2020). Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study. International Journal of Environmental Research and Public Health, 17(21), 7853. https://doi.org/10.3390/ijerph17217853

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