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Open AccessArticle

Biogenic Nanoparticle‒Chitosan Conjugates with Antimicrobial, Antibiofilm, and Anticancer Potentialities: Development and Characterization

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School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, China
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School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China
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School of Medical Science, Menzies Health Institute Queensland, Griffith University (Gold Coast campus), Parklands Drive, Southport, QLD 4222, Australia
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Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, 612 42 Brno, Czech Republic
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Department of Computer Science, Center for Advanced Studies in Agriculture and Food Security, University of Agriculture, Faisalabad 38040, Pakistan
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Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey, N.L. CP 64849, Mexico
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(4), 598; https://doi.org/10.3390/ijerph16040598
Received: 27 December 2018 / Revised: 31 January 2019 / Accepted: 14 February 2019 / Published: 19 February 2019
In the 21st century, with ever-increasing consciousness and social awareness, researchers must tackle the microbial infections that pose a major threat to human safety. For many reasons, the emergence/re-emergence of threatening pathogens has increased and poses a serious challenge to health care services. Considering the changing dynamics of 21st-century materials with medical potentialities, the integration of bioactive agents into materials to engineer antibacterial matrices has received limited attention so far. Thus, antimicrobial active conjugates are considered potential candidates to eradicate infections and reduce microbial contaminations in healthcare facilities. In this context, eco-friendly and novel conjugates with antimicrobial, antibiofilm, and anticancer potentialities were developed using biogenic silver nanoparticles (AgNPs) from Convolvulus arvensis (C. arvensis) extract and chitosan (CHI). A range of instrumental and imaging tools, i.e., UV-Vis and FTIR spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive spectroscopy (EDX), and X-ray diffraction (XRD), were employed to characterize the freshly extracted C. arvensis AgNPs. Biogenic AgNPs obtained after a 24-h reaction period were used to engineer CHI-based conjugates and designated as CHI‒AgNPs1 to CHI‒AgNPs5, subject to the C. arvensis AgNPs concentration. After the stipulated loading period, 92% loading efficiency (LE) was recorded for a CHI‒AgNPs3 conjugate. Gram+ and Gram- bacterial isolates, i.e., Staphylococcus aureus, and Escherichia coli, were used to test the antibacterial activities of newly developed CHI‒AgNPs conjugates. In comparison to the control sample with bacterial cell count 1.5 × 108 CFU/mL, a notable reduction in the log values was recorded for the CHI‒AgNPs3 conjugate. The antibiofilm potential of CHI‒AgNPs conjugates was tested against Pseudomonas aeruginosa. Moreover, the CHI‒AgNPs3 conjugate also showed substantial cytotoxicity against the MCF-7 (breast cancer) cell line. In summary, the newly engineered CHI‒AgNPs conjugates with antibacterial, antibiofilm, and anticancer potentialities are potential candidate materials for biomedical applications. View Full-Text
Keywords: Convolvulus arvensis; AgNPs; chitosan; antibacterial; antibiofilm; anticancer Convolvulus arvensis; AgNPs; chitosan; antibacterial; antibiofilm; anticancer
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MDPI and ACS Style

Bilal, M.; Zhao, Y.; Rasheed, T.; Ahmed, I.; Hassan, S.T.S.; Nawaz, M.Z.; Iqbal, H.M.N. Biogenic Nanoparticle‒Chitosan Conjugates with Antimicrobial, Antibiofilm, and Anticancer Potentialities: Development and Characterization. Int. J. Environ. Res. Public Health 2019, 16, 598. https://doi.org/10.3390/ijerph16040598

AMA Style

Bilal M, Zhao Y, Rasheed T, Ahmed I, Hassan STS, Nawaz MZ, Iqbal HMN. Biogenic Nanoparticle‒Chitosan Conjugates with Antimicrobial, Antibiofilm, and Anticancer Potentialities: Development and Characterization. International Journal of Environmental Research and Public Health. 2019; 16(4):598. https://doi.org/10.3390/ijerph16040598

Chicago/Turabian Style

Bilal, Muhammad; Zhao, Yuping; Rasheed, Tahir; Ahmed, Ishtiaq; Hassan, Sherif T.S.; Nawaz, Muhammad Z.; Iqbal, Hafiz M.N. 2019. "Biogenic Nanoparticle‒Chitosan Conjugates with Antimicrobial, Antibiofilm, and Anticancer Potentialities: Development and Characterization" Int. J. Environ. Res. Public Health 16, no. 4: 598. https://doi.org/10.3390/ijerph16040598

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