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Open AccessReview

A Submarine Journey: The Pyrrole-Imidazole Alkaloids

Department of Medicinal Chemistry, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano, Milano, Italy
Department of Chemical Core Technologies, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano, Milano, Italy
Author to whom correspondence should be addressed.
Dedicated to our colleague and friend Dr. Sergio Mantegani, in recognition of his merits in natural products chemistry, and in appreciation of his relentless endeavor to teach, advise and share his chemistry skills in our organization.
Mar. Drugs 2009, 7(4), 705-753;
Received: 30 October 2009 / Revised: 20 November 2009 / Accepted: 26 November 2009 / Published: 27 November 2009
(This article belongs to the Special Issue Synthesis around Marine Natural Products)
In his most celebrated tale “The Picture of Dorian Gray”, Oscar Wilde stated that “those who go beneath the surface do so at their peril”. This sentence could be a prophetical warning for the practitioner who voluntarily challenges himself with trying to synthesize marine sponge-deriving pyrrole-imidazole alkaloids. This now nearly triple-digit membered community has been growing exponentially in the last 20 years, both in terms of new representatives and topological complexity − from simple, achiral oroidin to the breathtaking 12-ring stylissadines A and B, each possessing 16 stereocenters. While the biosynthesis and the role in the sponge economy of most of these alkaloids still lies in the realm of speculations, significant biological activities for some of them have clearly emerged. This review will account for the progress in achieving the total synthesis of the more biologically enticing members of this class of natural products. View Full-Text
Keywords: pyrrole-imidazole alkaloids; total synthesis; marine sponges; oroidin pyrrole-imidazole alkaloids; total synthesis; marine sponges; oroidin
MDPI and ACS Style

Forte, B.; Malgesini, B.; Piutti, C.; Quartieri, F.; Scolaro, A.; Papeo, G. A Submarine Journey: The Pyrrole-Imidazole Alkaloids. Mar. Drugs 2009, 7, 705-753.

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