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Open AccessArticle

Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.

1
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
2
Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
3
Martini-Klinik, Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20251 Hamburg, Germany
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(6), 310; https://doi.org/10.3390/md18060310
Received: 26 May 2020 / Revised: 9 June 2020 / Accepted: 10 June 2020 / Published: 13 June 2020
(This article belongs to the Collection Marine Compounds and Cancer)
Leptogorgins A–C (13), new humulane sesquiterpenoids, and leptogorgoid A (4), a new dihydroxyketosteroid, were isolated from the gorgonian Leptogorgia sp. collected from the South China Sea. The structures were established using MS and NMR data. The absolute configuration of 1 was confirmed by a modification of Mosher’s method. Configurations of double bonds followed from NMR data, including NOE correlations. This is the first report of humulane-type sesquiterpenoids from marine invertebrates. Sesquiterpenoids leptogorgins A (1) and B (2) exhibited a moderate cytotoxicity and some selectivity against human drug-resistant prostate cancer cells 22Rv1. View Full-Text
Keywords: gorgonian; Leptogorgia; humulane sesquiterpenoids; anticancer activity gorgonian; Leptogorgia; humulane sesquiterpenoids; anticancer activity
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Kapustina, I.I.; Makarieva, T.N.; Guzii, A.G.; Kalinovsky, A.I.; Popov, R.S.; Dyshlovoy, S.A.; Grebnev, B.B.; von Amsberg, G.; Stonik, V.A. Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.. Mar. Drugs 2020, 18, 310.

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