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Quorum Sensing Inhibition by Marine Bacteria

LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal
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Mar. Drugs 2019, 17(7), 427; https://doi.org/10.3390/md17070427
Received: 22 May 2019 / Revised: 18 July 2019 / Accepted: 19 July 2019 / Published: 23 July 2019
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Abstract

Antibiotic resistance has been increasingly reported for a wide variety of bacteria of clinical significance. This widespread problem constitutes one of the greatest challenges of the twenty-first century. Faced with this issue, clinicians and researchers have been persuaded to design novel strategies in order to try to control pathogenic bacteria. Therefore, the discovery and elucidation of the mechanisms underlying bacterial pathogenesis and intercellular communication have opened new perspectives for the development of alternative approaches. Antipathogenic and/or antivirulence therapies based on the interruption of quorum sensing pathways are one of several such promising strategies aimed at disarming rather than at eradicating bacterial pathogens during the course of colonization and infection. This review describes mechanisms of bacterial communication involved in biofilm formation. An overview of the potential of marine bacteria and their bioactive components as QS inhibitors is further provided. View Full-Text
Keywords: antimicrobial resistance; antipathogenic and antivirulence; quorum sensing; quorum quenching; marine bacteria; selective pressure antimicrobial resistance; antipathogenic and antivirulence; quorum sensing; quorum quenching; marine bacteria; selective pressure
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Borges, A.; Simões, M. Quorum Sensing Inhibition by Marine Bacteria. Mar. Drugs 2019, 17, 427.

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