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Open AccessFeature PaperReview

Prostaglandins in Marine Organisms: A Review

Marine Biotechnology Department, Stazione Zoologica Anton Dohrn Napoli, Villa Comunale, 80121 Napoli, Italy
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(7), 428;
Received: 17 June 2019 / Revised: 15 July 2019 / Accepted: 19 July 2019 / Published: 23 July 2019
(This article belongs to the Special Issue Marine Anti-inflammatory Agents)
PDF [2265 KB, uploaded 23 July 2019]


Prostaglandins (PGs) are lipid mediators belonging to the eicosanoid family. PGs were first discovered in mammals where they are key players in a great variety of physiological and pathological processes, for instance muscle and blood vessel tone regulation, inflammation, signaling, hemostasis, reproduction, and sleep-wake regulation. These molecules have successively been discovered in lower organisms, including marine invertebrates in which they play similar roles to those in mammals, being involved in the control of oogenesis and spermatogenesis, ion transport, and defense. Prostaglandins have also been found in some marine macroalgae of the genera Gracilaria and Laminaria and very recently the PGs pathway has been identified for the first time in some species of marine microalgae. In this review we report on the occurrence of prostaglandins in the marine environment and discuss the anti-inflammatory role of these molecules. View Full-Text
Keywords: prostaglandins; clavulones; punaglandins; thromboxane; inflammation; marine vertebrates; marine invertebrates; diatoms; macroalgae prostaglandins; clavulones; punaglandins; thromboxane; inflammation; marine vertebrates; marine invertebrates; diatoms; macroalgae

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Di Costanzo, F.; Di Dato, V.; Ianora, A.; Romano, G. Prostaglandins in Marine Organisms: A Review. Mar. Drugs 2019, 17, 428.

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