Potential Antiviral Xanthones from a Coastal Saline Soil Fungus Aspergillus iizukae
AbstractFive new (1–5) and two known xanthones (6 and 7), one of the latter (6) obtained for the first time as a natural product, together with three known anthraquinones, questin, penipurdin A, and questinol, were isolated from the coastal saline soil-derived Aspergillus iizukae by application of an OSMAC (one strain many compounds) approach. Their structures were determined by interpretation of nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, as well as comparison of these data with those of related known compounds. Antiviral activity of xanthones 1−7 was evaluated through the cytopathic effect (CPE) inhibition assay, and compound 2 exhibited distinctly strong activity towards influenza virus (H1N1), herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) with IC50 values of 44.6, 21.4, and 76.7 μM, respectively, which indicated that it was worth to further investigate it as a potential lead compound. The preliminary structure-activity relationship of the xanthones is discussed. View Full-Text
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Kang, H.-H.; Zhang, H.-B.; Zhong, M.-J.; Ma, L.-Y.; Liu, D.-S.; Liu, W.-Z.; Ren, H. Potential Antiviral Xanthones from a Coastal Saline Soil Fungus Aspergillus iizukae. Mar. Drugs 2018, 16, 449.
Kang H-H, Zhang H-B, Zhong M-J, Ma L-Y, Liu D-S, Liu W-Z, Ren H. Potential Antiviral Xanthones from a Coastal Saline Soil Fungus Aspergillus iizukae. Marine Drugs. 2018; 16(11):449.Chicago/Turabian Style
Kang, Hui-Hui; Zhang, Huai-Bin; Zhong, Mei-Jia; Ma, Li-Ying; Liu, De-Sheng; Liu, Wei-Zhong; Ren, Hong. 2018. "Potential Antiviral Xanthones from a Coastal Saline Soil Fungus Aspergillus iizukae." Mar. Drugs 16, no. 11: 449.
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