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Mar. Drugs 2018, 16(11), 449; https://doi.org/10.3390/md16110449

Potential Antiviral Xanthones from a Coastal Saline Soil Fungus Aspergillus iizukae

1
College of Pharmacy, Binzhou Medical University, Yantai 264003, China
2
Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Key Laboratory of Flavor Chemistry, Beijing Laboratory for Food Quality and Safety, Beijing Technology and Business University, Beijing 100048, China
*
Authors to whom correspondence should be addressed.
Received: 27 October 2018 / Revised: 13 November 2018 / Accepted: 14 November 2018 / Published: 15 November 2018
(This article belongs to the Special Issue Isolation and Structure Elucidation of Marine Secondary Metabolites)
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Abstract

Five new (15) and two known xanthones (6 and 7), one of the latter (6) obtained for the first time as a natural product, together with three known anthraquinones, questin, penipurdin A, and questinol, were isolated from the coastal saline soil-derived Aspergillus iizukae by application of an OSMAC (one strain many compounds) approach. Their structures were determined by interpretation of nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, as well as comparison of these data with those of related known compounds. Antiviral activity of xanthones 17 was evaluated through the cytopathic effect (CPE) inhibition assay, and compound 2 exhibited distinctly strong activity towards influenza virus (H1N1), herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) with IC50 values of 44.6, 21.4, and 76.7 μM, respectively, which indicated that it was worth to further investigate it as a potential lead compound. The preliminary structure-activity relationship of the xanthones is discussed. View Full-Text
Keywords: Aspergillus iizukae; xanthones; antiviral activity; structure-activity relationship Aspergillus iizukae; xanthones; antiviral activity; structure-activity relationship
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Kang, H.-H.; Zhang, H.-B.; Zhong, M.-J.; Ma, L.-Y.; Liu, D.-S.; Liu, W.-Z.; Ren, H. Potential Antiviral Xanthones from a Coastal Saline Soil Fungus Aspergillus iizukae. Mar. Drugs 2018, 16, 449.

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