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Open AccessArticle

Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10

1
Engineering Research Center of Marine Biological Resource Comprehensive Utilization, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China
2
Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China
3
Institute of Drug Discovery Technology, Ningbo University, Ningbo 315832, China
4
Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
*
Author to whom correspondence should be addressed.
These authors contribute equally to this paper.
Mar. Drugs 2018, 16(11), 428; https://doi.org/10.3390/md16110428
Received: 20 October 2018 / Revised: 27 October 2018 / Accepted: 30 October 2018 / Published: 2 November 2018
To investigate structurally novel and anti-neuroinflammatory natural compounds from marine-derived microorganisms, the secondary metabolites of Aspergillus terreus Y10, a fungus separated from the sediment of the coast in the South China Sea, were studied. Three new compounds (24), with novel open-ring butenolide skeletons, were isolated from the ethyl acetate extract of the culture medium. In addition, a typical new butenolide, asperteretal F (1), was found to dose-dependently inhibit tumor necrosis factor (TNF-α) generation with an IC50 of 7.6 μg/mL. The present study shows the existence of open-ring butenolides, and suggests that butenolides such as asperteretal F (1) are a promising new anti-neuroinflammatroy candidate for neurodegenerative diseases. View Full-Text
Keywords: Aspergillus terreus Y10; asperteretal F; G1; G2; H; open-ring butenolide; microglial; anti-neuroinflammatory activity Aspergillus terreus Y10; asperteretal F; G1; G2; H; open-ring butenolide; microglial; anti-neuroinflammatory activity
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MDPI and ACS Style

Yang, L.-H.; Ou-Yang, H.; Yan, X.; Tang, B.-W.; Fang, M.-J.; Wu, Z.; Chen, J.-W.; Qiu, Y.-K. Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10. Mar. Drugs 2018, 16, 428. https://doi.org/10.3390/md16110428

AMA Style

Yang L-H, Ou-Yang H, Yan X, Tang B-W, Fang M-J, Wu Z, Chen J-W, Qiu Y-K. Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10. Marine Drugs. 2018; 16(11):428. https://doi.org/10.3390/md16110428

Chicago/Turabian Style

Yang, Long-He; Ou-Yang, Han; Yan, Xia; Tang, Bo-Wen; Fang, Mei-Juan; Wu, Zhen; Chen, Jing-Wei; Qiu, Ying-Kun. 2018. "Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10" Mar. Drugs 16, no. 11: 428. https://doi.org/10.3390/md16110428

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