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Keywords = asperteretal F

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10 pages, 3534 KiB  
Article
Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10
by Long-He Yang, Han Ou-Yang, Xia Yan, Bo-Wen Tang, Mei-Juan Fang, Zhen Wu, Jing-Wei Chen and Ying-Kun Qiu
Mar. Drugs 2018, 16(11), 428; https://doi.org/10.3390/md16110428 - 2 Nov 2018
Cited by 23 | Viewed by 3863
Abstract
To investigate structurally novel and anti-neuroinflammatory natural compounds from marine-derived microorganisms, the secondary metabolites of Aspergillus terreus Y10, a fungus separated from the sediment of the coast in the South China Sea, were studied. Three new compounds (24), with [...] Read more.
To investigate structurally novel and anti-neuroinflammatory natural compounds from marine-derived microorganisms, the secondary metabolites of Aspergillus terreus Y10, a fungus separated from the sediment of the coast in the South China Sea, were studied. Three new compounds (24), with novel open-ring butenolide skeletons, were isolated from the ethyl acetate extract of the culture medium. In addition, a typical new butenolide, asperteretal F (1), was found to dose-dependently inhibit tumor necrosis factor (TNF-α) generation with an IC50 of 7.6 μg/mL. The present study shows the existence of open-ring butenolides, and suggests that butenolides such as asperteretal F (1) are a promising new anti-neuroinflammatroy candidate for neurodegenerative diseases. Full article
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