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Bioactive Compounds Produced by Strains of Penicillium and Talaromyces of Marine Origin

Council for Agricultural Research and Agricultural Economy Analysis, Rome 00184, Italy
Institute of Biomolecular Chemistry, National Research Council, Pozzuoli 80078, Italy
Author to whom correspondence should be addressed.
Current address: Department of Agriculture, University of Naples “Federico II”, Portici 80055, Italy
Academic Editor: Orazio Taglialatela-Scafati
Mar. Drugs 2016, 14(2), 37;
Received: 23 December 2015 / Revised: 22 January 2016 / Accepted: 25 January 2016 / Published: 18 February 2016
PDF [2135 KB, uploaded 18 February 2016]


In recent years, the search for novel natural compounds with bioactive properties has received a remarkable boost in view of their possible pharmaceutical exploitation. In this respect the sea is entitled to hold a prominent place, considering the potential of the manifold animals and plants interacting in this ecological context, which becomes even greater when their associated microbes are considered for bioprospecting. This is the case particularly of fungi, which have only recently started to be considered for their fundamental contribution to the biosynthetic potential of other more valued marine organisms. Also in this regard, strains of species which were previously considered typical terrestrial fungi, such as Penicillium and Talaromyces, disclose foreground relevance. This paper offers an overview of data published over the past 25 years concerning the production and biological activities of secondary metabolites of marine strains belonging to these genera, and their relevance as prospective drugs. View Full-Text
Keywords: bioactive metabolites; chemodiversity; marine fungi; Penicillium; Talaromyces bioactive metabolites; chemodiversity; marine fungi; Penicillium; Talaromyces

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Nicoletti, R.; Trincone, A. Bioactive Compounds Produced by Strains of Penicillium and Talaromyces of Marine Origin. Mar. Drugs 2016, 14, 37.

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