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Mar. Drugs 2016, 14(2), 38;

Biosurfactants Produced by Marine Microorganisms with Therapeutic Applications

CEB—Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal
Author to whom correspondence should be addressed.
Academic Editor: Paul Long
Received: 30 November 2015 / Revised: 29 January 2016 / Accepted: 1 February 2016 / Published: 18 February 2016
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Marine microorganisms possess unique metabolic and physiological features and are an important source of new biomolecules, such as biosurfactants. Some of these surface-active compounds synthesized by marine microorganisms exhibit antimicrobial, anti-adhesive and anti-biofilm activity against a broad spectrum of human pathogens (including multi-drug resistant pathogens), and could be used instead of existing drugs to treat infections caused by them. In other cases, these biosurfactants show anti-cancer activity, which could be envisaged as an alternative to conventional therapies. However, marine biosurfactants have not been widely explored, mainly due to the difficulties associated with the isolation and growth of their producing microorganisms. Culture-independent techniques (metagenomics) constitute a promising approach to study the genetic resources of otherwise inaccessible marine microorganisms without the requirement of culturing them, and can contribute to the discovery of novel biosurfactants with significant biological activities. This paper reviews the most relevant biosurfactants produced by marine microorganisms with potential therapeutic applications and discusses future perspectives and opportunities to discover novel molecules from marine environments. View Full-Text
Keywords: biosurfactant; antimicrobial activity; anti-adhesive activity; anti-biofilm activity; anti-cancer activity; metagenomics biosurfactant; antimicrobial activity; anti-adhesive activity; anti-biofilm activity; anti-cancer activity; metagenomics

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Gudiña, E.J.; Teixeira, J.A.; Rodrigues, L.R. Biosurfactants Produced by Marine Microorganisms with Therapeutic Applications. Mar. Drugs 2016, 14, 38.

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