The Relationship Between Thrombophilia and Modifications in First-Trimester Prenatal Screening Markers
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Study Population
2.3. Assessment of Thrombophilic Mutations
2.4. First-Trimester Screening
2.5. Data Collection
2.6. Statistical Analysis
3. Results
3.1. Demographic Description
3.2. Risk Factors
3.3. Ultrasound Parameters
3.4. Correlation
3.5. Relative Risk
3.6. Multivariate Linear Regression
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameters | Groups | Total | ||||
---|---|---|---|---|---|---|
I | II | |||||
Mean | SD | Mean | SD | Mean | SD | |
Age | 29.84 | 3.97 | 34.00 | 3.87 | 32.30 | 4.40 |
Maternal weight | 68.74 | 13.62 | 66.98 | 12.49 | 67.70 | 12.93 |
Height | 163.79 | 5.03 | 166.19 | 6.36 | 165.21 | 5.94 |
BMI | 25.60 | 4.91 | 24.20 | 3.92 | 24.77 | 4.39 |
Weeks pregnant | 11.95 | 0.65 | 12.52 | 0.74 | 12.29 | 0.76 |
Days of pregnancy accuracy | 3.35 | 2.06 | 3.37 | 2.13 | 3.36 | 2.09 |
Parity | 0.98 | 1.26 | 0.74 | 0.85 | 0.84 | 1.04 |
Pearson Correlation | Age | Maternal Weight | Height | BMI | Weeks Pregnant | Days of Pregnancy | |
---|---|---|---|---|---|---|---|
LCC | r | 0.240 * | −0.021 | 0.046 | −0.047 | 0.867 ** | 0.104 |
p | 0.014 | 0.834 | 0.641 | 0.632 | 0.000 | 0.291 | |
TN IN MM | r | 0.210 * | 0.042 | 0.193 * | −0.042 | 0.471 ** | 0.036 |
p | 0.031 | 0.671 | 0.049 | 0.673 | 0.000 | 0.719 | |
Free B HCG | r | 0.034 | −0.264 ** | 0.099 | −0.329 ** | −0.216 * | −0.020 |
p | 0.729 | 0.007 | 0.313 | 0.001 | 0.027 | 0.840 | |
Free B HCG MOM | r | 0.050 | −0.093 | 0.166 | −0.176 | −0.075 | −0.044 |
p | 0.612 | 0.344 | 0.090 | 0.073 | 0.450 | 0.655 | |
PAPP A | r | 0.059 | −0.249 * | −0.047 | −0.247 * | 0.167 | 0.130 |
p | 0.550 | 0.010 | 0.635 | 0.011 | 0.090 | 0.186 | |
PAPP A MOM | r | 0.209 * | −0.048 | 0.111 | −0.096 | 0.081 | 0.003 |
p | 0.032 | 0.630 | 0.261 | 0.329 | 0.411 | 0.977 | |
N | 105 |
Pearson Correlation | LCC | TN IN MM | Free B HCG | Free B HCG MoM | PAPP A | PAPP A MoM | |
---|---|---|---|---|---|---|---|
LCC | r | 1 | 0.551 ** | −0.182 | −0.034 | 0.232 * | 0.115 |
p | - | 0.000 | 0.064 | 0.728 | 0.017 | 0.243 | |
TN IN MM | r | 0.551 ** | 1 | −0.238 * | −0.255 ** | −0.036 | 0.058 |
p | 0.000 | - | 0.014 | 0.009 | 0.716 | 0.556 | |
Free B HCG | r | −0.182 | −0.238 * | 1 | 0.902 ** | 0.161 | 0.231 * |
p | 0.064 | 0.014 | - | 0.000 | 0.101 | 0.018 | |
Free B HCG MoM | r | −0.034 | −0.255 ** | 0.902 ** | 1 | 0.259 ** | 0.298 ** |
p | 0.728 | 0.009 | 0.000 | - | 0.008 | 0.002 | |
PAPP A | r | 0.232 * | −0.036 | 0.161 | 0.259 ** | 1 | 0.789 ** |
p | 0.017 | 0.716 | 0.101 | 0.008 | - | 0.000 | |
PAPP A MoM | r | 0.115 | 0.058 | 0.231 * | 0.298 ** | 0.789 ** | 1 |
p | 0.243 | 0.556 | 0.018 | 0.002 | 0.000 | - | |
N | 105 | 105 | 105 | 105 | 105 | 105 |
Predictor | Effect on PAPP-A | Significance | Effect on NT | Significance | Predictor |
---|---|---|---|---|---|
Smoking | Negative | No | Negative | No | Smoking |
Chronic Hypertension | Positive | No | Positive | No | Chronic Hypertension |
Pregnancy-Induced Hypertension | Minimal | No | Minimal | No | Pregnancy-Induced Hypertension |
Parity | Negative | Yes (p = 0.026) | Negative | Borderline (p = 0.079) | Parity |
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Murvai, V.R.; Radu, C.-M.; Galiș, R.; Ghitea, T.C.; Tătaru-Copos, A.-F.; Vesa, A.-A.; Huniadi, A. The Relationship Between Thrombophilia and Modifications in First-Trimester Prenatal Screening Markers. Medicina 2025, 61, 318. https://doi.org/10.3390/medicina61020318
Murvai VR, Radu C-M, Galiș R, Ghitea TC, Tătaru-Copos A-F, Vesa A-A, Huniadi A. The Relationship Between Thrombophilia and Modifications in First-Trimester Prenatal Screening Markers. Medicina. 2025; 61(2):318. https://doi.org/10.3390/medicina61020318
Chicago/Turabian StyleMurvai, Viorela Romina, Casandra-Maria Radu, Radu Galiș, Timea Claudia Ghitea, Anca-Florina Tătaru-Copos, Alexandra-Alina Vesa, and Anca Huniadi. 2025. "The Relationship Between Thrombophilia and Modifications in First-Trimester Prenatal Screening Markers" Medicina 61, no. 2: 318. https://doi.org/10.3390/medicina61020318
APA StyleMurvai, V. R., Radu, C.-M., Galiș, R., Ghitea, T. C., Tătaru-Copos, A.-F., Vesa, A.-A., & Huniadi, A. (2025). The Relationship Between Thrombophilia and Modifications in First-Trimester Prenatal Screening Markers. Medicina, 61(2), 318. https://doi.org/10.3390/medicina61020318