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Vulnerability Factors for the Psychiatric and Behavioral Effects of Cannabis

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90033, USA
Tourette Syndrome Center, University of Cagliari, Italy
Department of Neuroscience “Bernard B. Brodie”, University of Cagliari, Italy
Neuroscience PharmaNess, S.C.A.R.L., Edificio 5, Parco Scientifico e Tecnologico della Sardegna, Località Piscinamanna, Pula, Cagliari, Italy
Author to whom correspondence should be addressed.
Pharmaceuticals 2010, 3(9), 2799-2820;
Received: 29 July 2010 / Revised: 23 August 2010 / Accepted: 25 August 2010 / Published: 26 August 2010
(This article belongs to the Special Issue Cannabinoids)
Cogent evidence shows that cannabis plays a variable role on behavioral regulation and the pathophysiology of most psychiatric conditions. Accordingly, cannabis has been alternatively shown to exacerbate or ameliorate mental symptoms, depending on its composition and route of consumption, as well as specific individual and contextual characteristics. The vulnerability to the psychological effects of cannabis is influenced by a complex constellation of genetic and environmental factors. In the present article, we will review the current evidence on the pharmacological, individual and situational factors that have been documented to affect the behavioral and psychiatric effects of cannabinoids. View Full-Text
Keywords: cannabinoids; vulnerability; CB receptors cannabinoids; vulnerability; CB receptors
MDPI and ACS Style

Bortolato, M.; Bini, V.; Tambaro, S. Vulnerability Factors for the Psychiatric and Behavioral Effects of Cannabis. Pharmaceuticals 2010, 3, 2799-2820.

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