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Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain

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Nerve-Gut Research Laboratory, Department of Gastroenterology & Hepatology, Hanson Institute, Royal Adelaide Hospital, Adelaide, South Australia, 5000, Australia
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Disciplines of Medicine, The University of Adelaide, Adelaide, South Australia, 5000, Australia
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Disciplines of Physiology, The University of Adelaide, Adelaide, South Australia, 5000, Australia
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2010, 3(9), 2768-2798; https://doi.org/10.3390/ph3092768
Received: 13 July 2010 / Revised: 5 August 2010 / Accepted: 20 August 2010 / Published: 26 August 2010
(This article belongs to the Special Issue Ion Channels as Therapeutic Targets for Pain)
We are normally unaware of the complex signalling events which continuously occur within our internal organs. Most of us only become cognisant when sensations of hunger, fullness, urgency or gas arise. However, for patients with organic and functional bowel disorders pain is an unpleasant and often debilitating reminder. Furthermore, chronic pain still represents a large unmet need for clinical treatment. Consequently, chronic pain has a considerable economic impact on health care systems and the afflicted individuals. In order to address this need we must understand how symptoms are generated within the gut, the molecular pathways responsible for generating these signals and how this process changes in disease states. View Full-Text
Keywords: TRPA1; TRPV4; TRPV1; ASICs; NaV and KV channels; visceral pain TRPA1; TRPV4; TRPV1; ASICs; NaV and KV channels; visceral pain
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Brierley, S.M.; Hughes, P.A.; Harrington, A.M.; Rychkov, G.Y.; Blackshaw, L.A. Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain. Pharmaceuticals 2010, 3, 2768-2798.

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