Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia

Szudzik, Mateusz; Starzyński, Rafał R.; Jończy, Aneta; Mazgaj, Rafał; Lenartowicz, Małgorzata; Lipiński, Paweł

doi:10.3390/ph11040128

Submit to this Journal Review for this Journal Edit a Special Issue

Article Menu

Printed Edition

A printed edition of this Special Issue is available at MDPI Books....

...

Correction published on 29 January 2019, see Pharmaceuticals 2019, 12(1), 22.

Open AccessReview

Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia

¹,

¹,

Małgorzata Lenartowicz

² and

Paweł Lipiński

^1,3,*

Department of Molecular Biology, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzębiec, 05-552 Magdalenka, Poland

Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Gronostajowa 9, 30-387 Kraków, Poland

Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wołyńska 33, 60-637 Poznań, Poland

Author to whom correspondence should be addressed.

Pharmaceuticals 2018, 11(4), 128; https://doi.org/10.3390/ph11040128

Received: 9 October 2018 / Revised: 7 November 2018 / Accepted: 19 November 2018 / Published: 22 November 2018

(This article belongs to the Special Issue Iron as Therapeutic Targets in Human Diseases)

View Full-Text Download PDF

Browse Figures

Citation Export

Abstract

In pigs, iron deficiency anemia (IDA) is the most prevalent deficiency disorder during the early postnatal period, frequently developing into a serious illness. On the other hand, in humans, only low-birth-weight infants, including premature infants, are especially susceptible to developing IDA. In both human and pig neonates, the initial cause of IDA is low birth iron stores. In piglets this shortage of stored iron results mainly from genetic selection over the past few decades for large litter sizes and high birth weights. As a consequence, pregnant sows cannot provide a sufficient amount of iron to the increasing number of developing fetuses. Supplementation with iron is a common practice for the treatment of IDA in piglets. For decades, the preferred procedure for delivering iron supplements during early life stages has been through the intramuscular injection of a large amount of iron dextran. However, this relatively simple therapy, which in general, efficiently corrects IDA, may generate toxic effects, and by inducing hepcidin expression, may decrease bioavailability of supplemental iron. New iron supplements are considered herein with the aim to combine the improvement of hematological status, blunting of hepcidin expression, and minimizing the toxicity of the administered iron. We propose that iron-deficient piglets constitute a convenient animal model for performing pre-clinical studies with iron supplements. View Full-Text

Keywords: hepcidin; iron deficiency anemia; iron dextran; neonatal period; pig; supplementation

▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Share and Cite

MDPI and ACS Style

Szudzik, M.; Starzyński, R.R.; Jończy, A.; Mazgaj, R.; Lenartowicz, M.; Lipiński, P. Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia. Pharmaceuticals 2018, 11, 128. https://doi.org/10.3390/ph11040128

AMA Style

Szudzik M, Starzyński RR, Jończy A, Mazgaj R, Lenartowicz M, Lipiński P. Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia. Pharmaceuticals. 2018; 11(4):128. https://doi.org/10.3390/ph11040128

Chicago/Turabian Style

Szudzik, Mateusz, Rafał R. Starzyński, Aneta Jończy, Rafał Mazgaj, Małgorzata Lenartowicz, and Paweł Lipiński. 2018. "Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia" Pharmaceuticals 11, no. 4: 128. https://doi.org/10.3390/ph11040128

Find Other Styles

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Abstract views Pdf views Html views

Article Menu

Printed Edition

Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Article Access Map by Country/Region

Further Information

Guidelines

MDPI Initiatives

Follow MDPI