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Article

Functional Connectivity and Frequency Power Alterations during P300 Task as a Result of Amyotrophic Lateral Sclerosis

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Escuela de Ingeniería y Ciencias, Tecnologico de Monterrey, Monterrey 64849, Mexico
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Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Monterrey 64849, Mexico
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Author to whom correspondence should be addressed.
Academic Editor: Yvonne Tran
Sensors 2021, 21(20), 6801; https://doi.org/10.3390/s21206801
Received: 1 August 2021 / Revised: 22 September 2021 / Accepted: 26 September 2021 / Published: 13 October 2021
(This article belongs to the Special Issue EEG Signal Processing for Biomedical Applications)
Amyotrophic Lateral Sclerosis (ALS) is one of the most aggressive neurodegenerative diseases and is now recognized as a multisystem network disorder with impaired connectivity. Further research for the understanding of the nature of its cognitive affections is necessary to monitor and detect the disease, so this work provides insight into the neural alterations occurring in ALS patients during a cognitive task (P300 oddball paradigm) by measuring connectivity and the power and latency of the frequency-specific EEG activity of 12 ALS patients and 16 healthy subjects recorded during the use of a P300-based BCI to command a robotic arm. For ALS patients, in comparison to Controls, the results (p < 0.05) were: an increment in latency of the peak ERP in the Delta range (OZ) and Alpha range (PO7), and a decreased power in the Beta band among most electrodes; connectivity alterations among all bands, especially in the Alpha band between PO7 and the channels above the motor cortex. The evolution observed over months of an advanced-state patient backs up these findings. These results were used to compute connectivity- and power-based features to discriminate between ALS and Control groups using Support Vector Machine (SVM). Cross-validation achieved a 100% in specificity and 75% in sensitivity, with an overall 89% success. View Full-Text
Keywords: ALS; EEG; classifier; neural; connectivity; frequency-specific; BCI ALS; EEG; classifier; neural; connectivity; frequency-specific; BCI
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MDPI and ACS Style

Perez-Ortiz, C.X.; Gordillo, J.L.; Mendoza-Montoya, O.; Antelis, J.M.; Caraza, R.; Martinez, H.R. Functional Connectivity and Frequency Power Alterations during P300 Task as a Result of Amyotrophic Lateral Sclerosis. Sensors 2021, 21, 6801. https://doi.org/10.3390/s21206801

AMA Style

Perez-Ortiz CX, Gordillo JL, Mendoza-Montoya O, Antelis JM, Caraza R, Martinez HR. Functional Connectivity and Frequency Power Alterations during P300 Task as a Result of Amyotrophic Lateral Sclerosis. Sensors. 2021; 21(20):6801. https://doi.org/10.3390/s21206801

Chicago/Turabian Style

Perez-Ortiz, Claudia X., Jose L. Gordillo, Omar Mendoza-Montoya, Javier M. Antelis, Ricardo Caraza, and Hector R. Martinez 2021. "Functional Connectivity and Frequency Power Alterations during P300 Task as a Result of Amyotrophic Lateral Sclerosis" Sensors 21, no. 20: 6801. https://doi.org/10.3390/s21206801

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