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Open AccessArticle

Smartphone Biosensor System with Multi-Testing Unit Based on Localized Surface Plasmon Resonance Integrated with Microfluidics Chip

1
State Key Laboratory of Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China
2
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
3
School of Information Engineering, Minzu University of China, Beijing 100081, China
4
State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(2), 446; https://doi.org/10.3390/s20020446
Received: 29 November 2019 / Revised: 29 December 2019 / Accepted: 9 January 2020 / Published: 13 January 2020
(This article belongs to the Section Biosensors)
Detecting biomarkers is an efficient method to diagnose and monitor patients’ stages. For more accurate diagnoses, continuously detecting and monitoring multiple biomarkers are needed. To achieve point-of-care testing (POCT) of multiple biomarkers, a smartphone biosensor system with the multi-testing-unit (SBSM) based on localized surface plasmon resonance (LSPR) integrated multi-channel microfluidics was presented. The SBSM could simultaneously record nine sensor units to achieve the detection of multiple biomarkers. Additional 72 sensor units were fabricated for further verification. Well-designed modularized attachments consist of a light source, lenses, a grating, a case, and a smartphone shell. The attachments can be well assembled and attached to a smartphone. The sensitivity of the SBSM was 161.0 nm/RIU, and the limit of detection (LoD) reached 4.2 U/mL for CA125 and 0.87 U/mL for CA15-3 through several clinical serum specimens testing on the SBSM. The testing results indicated that the SBSM was a useful tool for detecting multi-biomarkers. Comparing with the enzyme-linked immunosorbent assays (ELISA) results, the results from the SBSM were correlated and reliable. Meanwhile, the SBSM was convenient to operate without much professional skill. Therefore, the SBSM could become useful equipment for point-of-care testing due to its small size, multi-testing unit, usability, and customizable design. View Full-Text
Keywords: localized surface plasmon resonance; smartphone; multipoint biosensor; microfluidics; point-of-care; protein detection localized surface plasmon resonance; smartphone; multipoint biosensor; microfluidics; point-of-care; protein detection
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Fan, Z.; Geng, Z.; Fang, W.; Lv, X.; Su, Y.; Wang, S.; Chen, H. Smartphone Biosensor System with Multi-Testing Unit Based on Localized Surface Plasmon Resonance Integrated with Microfluidics Chip. Sensors 2020, 20, 446.

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