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Sensors 2017, 17(12), 2777; https://doi.org/10.3390/s17122777

A Sensitive and Stable Surface Plasmon Resonance Sensor Based on Monolayer Protected Silver Film

1
Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
2
Department of Physics, Tsinghua University, Beijing 100084, China
3
The Central Laboratory, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen 518035, China
*
Author to whom correspondence should be addressed.
Received: 30 September 2017 / Revised: 8 November 2017 / Accepted: 14 November 2017 / Published: 30 November 2017
(This article belongs to the Special Issue Surface Plasmon Resonance Sensing)
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Abstract

In this paper, we present a stable silver-based surface plasmon resonance (SPR) sensor using a self-assembled monolayer (SAM) as a protection layer and investigated its efficiency in water and 0.01 M phosphate buffered saline (PBS). By simulation, silver-based SPR sensor has a better performance in field enhancement and penetration depth than that of a gold-based SPR sensor, which are 5 and 1.4 times, respectively. To overcome the instability of the bare silver film and investigate the efficiency of the protected layer, the SAM of 11-mercapto-1-undecanol (MUD) was used as a protection layer. Stability experiment results show that the protected silver film exhibited excellent stability either in pure water or 0.01 M PBS buffer. The sensitivity of the silver-based SPR sensor was calculated to be 127.26 deg/RIU (refractive index unit), measured with different concentrations of NaCl solutions. Further, a very high refractive resolution for the silver-based SPR sensor was found to be 2.207 × 10−7 RIU, which reaches the theoretical limit in the wavelength of 632.8 nm for a SPR sensor reported in the literature. Using a mixed SAM of 16-mercaptohexadecanoic acid (MHDA) and a MUD layer with a ratio of 1:10, this immunosensor for the rabbit immunoglobulin G (IgG) molecule with a limit of detection as low as 22.516 ng/mL was achieved. View Full-Text
Keywords: silver film; surface plasmon resonance; chemical stability; self-assembled monolayer (SAM) silver film; surface plasmon resonance; chemical stability; self-assembled monolayer (SAM)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Wang, G.; Wang, C.; Yang, R.; Liu, W.; Sun, S. A Sensitive and Stable Surface Plasmon Resonance Sensor Based on Monolayer Protected Silver Film. Sensors 2017, 17, 2777.

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