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Communication

Synthesis of Bisoxazole and Bromo-substituted Aryloxazoles

Department of Chemistry, Indian Institute of Technology, Bombay 400076, India
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Author to whom correspondence should be addressed.
Academic Editor: Panayiotis A. Koutentis
Molbank 2022, 2022(3), M1440; https://doi.org/10.3390/M1440
Received: 29 July 2022 / Revised: 1 September 2022 / Accepted: 1 September 2022 / Published: 6 September 2022
(This article belongs to the Section Organic Synthesis)
Herein, we report a bisoxazole derivative as well as a bromo-substituted oxazole derivatives via a simple approach. The synthesis begins with an inexpensive and readily available starting material, such as 2,5-dimethoxybenzaldehyde, hydroquinone, and p-toluenesulfonylmethyl isocyanide (TosMIC). This approach relies on the Van Leusen oxazole method and electrophilic aromatic bromination. The structures of bisoxazole and bromosubstituted aryloxazoles were fully supported by spectroscopic methods (IR, NMR, and HRMS) and further established using single crystal X-ray diffraction studies. View Full-Text
Keywords: heterocycles; 1,3-oxazole motifs; TosMIC; Van Leusen reaction; bisoxazole; electrophilic aromatic bromination heterocycles; 1,3-oxazole motifs; TosMIC; Van Leusen reaction; bisoxazole; electrophilic aromatic bromination
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MDPI and ACS Style

Kotha, S.; Cheekatla, S.R. Synthesis of Bisoxazole and Bromo-substituted Aryloxazoles. Molbank 2022, 2022, M1440. https://doi.org/10.3390/M1440

AMA Style

Kotha S, Cheekatla SR. Synthesis of Bisoxazole and Bromo-substituted Aryloxazoles. Molbank. 2022; 2022(3):M1440. https://doi.org/10.3390/M1440

Chicago/Turabian Style

Kotha, Sambasivarao, and Subba Rao Cheekatla. 2022. "Synthesis of Bisoxazole and Bromo-substituted Aryloxazoles" Molbank 2022, no. 3: M1440. https://doi.org/10.3390/M1440

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