Next Article in Journal
Synthesis of Bisoxazole and Bromo-substituted Aryloxazoles
Previous Article in Journal
1,1′-{[3,5-Bis((dodecyloxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl]bis(methylene)}bis[4-(anthracen-9-yl)pyridin-1-ium] Dibromide
Previous Article in Special Issue
Short Note

Dichloro{4-(4-chlorophenoxy)phthalazin-1-yl} methylphosphonic dichloride

Aix Marseille Univ, CNRS, ICR UMR 7273, Equipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, CEDEX 05, 13385 Marseille, France
APHM, Hôpital Conception, Service Central de la Qualité et de l’Information Pharmaceutiques, 13005 Marseille, France
Authors to whom correspondence should be addressed.
Academic Editors: Stefano D’Errico and Annalisa Guaragna
Molbank 2022, 2022(3), M1439;
Received: 12 August 2022 / Revised: 1 September 2022 / Accepted: 2 September 2022 / Published: 5 September 2022
(This article belongs to the Special Issue Molecules from Side Reactions II)
As part of our ongoing scaffold-hopping work on an antiplasmodial 2-trichloromethylquinazoline scaffold, we aimed to explore the 1-trichloromethylphthalazine scaffold as a potential new antimalarial series. Using previously chlorination conditions described by our lab to obtain a trichloromethyl group from a methyl group, we did not obtain the target compound; instead, we obtained a dichloro methylphosphonic dichloride side product 3. The nature of this compound was then characterized by NMR, HRMS and X-ray crystallography. The same issue was previously reported by Kato et al., starting from the 2-methyl-3-nitropyridine. Finally, compound 3, although not cytotoxic, was not active against P. falciparum, the parasite responsible for human malaria. View Full-Text
Keywords: phthalazine; chlorination; side product; phosphonic dichloride; P. falciparum; HepG2 phthalazine; chlorination; side product; phosphonic dichloride; P. falciparum; HepG2
Show Figures

Figure 1

MDPI and ACS Style

Amrane, D.; Khoumeri, O.; Vanelle, P.; Primas, N. Dichloro{4-(4-chlorophenoxy)phthalazin-1-yl} methylphosphonic dichloride. Molbank 2022, 2022, M1439.

AMA Style

Amrane D, Khoumeri O, Vanelle P, Primas N. Dichloro{4-(4-chlorophenoxy)phthalazin-1-yl} methylphosphonic dichloride. Molbank. 2022; 2022(3):M1439.

Chicago/Turabian Style

Amrane, Dyhia, Omar Khoumeri, Patrice Vanelle, and Nicolas Primas. 2022. "Dichloro{4-(4-chlorophenoxy)phthalazin-1-yl} methylphosphonic dichloride" Molbank 2022, no. 3: M1439.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop