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(R,S)-2-{[4-(4-Methylphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenyl-1-ethanol

Department of Applied Chemistry and Organic and Natural Compounds Engineering, Politehnica University Timisoara, Carol Telbisz 6, RO-300001 Timisoara, Romania
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Academic Editor: Nicholas E. Leadbeater
Molbank 2021, 2021(3), M1241; https://doi.org/10.3390/M1241
Received: 15 May 2021 / Revised: 7 June 2021 / Accepted: 9 June 2021 / Published: 1 July 2021
(This article belongs to the Section Organic Synthesis)
4-(4-Methylphenyl)-5-phenyl-4H-1,2,4-triazol-3-thiol (4) was alkylated to 2-{[4-(4-methylphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenylethan-1-one (5) in alkaline conditions using 2-bromo-1-phenylethanone. The alkylated compound (5) was reduced at the carbonyl group to the corresponding racemic secondary alcohol with an asymmetric carbon, (R,S)-2-{[4-(4-methylphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenyl-1-ethanol (6). Both synthesized compounds, ketone (5) and secondary alcohol (6), are new and have not yet been reported in the literature. All the synthesized compounds were characterized by IR, 1D and 2D 1H-1H, 1H-13C and 1H-15N NMR spectroscopy and by elemental analysis. View Full-Text
Keywords: 1,2,4-triazole-3-thiol; S-alkylation; secondary heterocyclic alcohol; racemic 1,2,4-triazole-3-thiol; S-alkylation; secondary heterocyclic alcohol; racemic
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MDPI and ACS Style

Valicsek, V.-S.; Badea, V. (R,S)-2-{[4-(4-Methylphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenyl-1-ethanol. Molbank 2021, 2021, M1241. https://doi.org/10.3390/M1241

AMA Style

Valicsek V-S, Badea V. (R,S)-2-{[4-(4-Methylphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenyl-1-ethanol. Molbank. 2021; 2021(3):M1241. https://doi.org/10.3390/M1241

Chicago/Turabian Style

Valicsek, Vladislav-Silvestru, and Valentin Badea. 2021. "(R,S)-2-{[4-(4-Methylphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenyl-1-ethanol" Molbank 2021, no. 3: M1241. https://doi.org/10.3390/M1241

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