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(E)-5-Benzyl-7-(3,4-dimethoxybenzylidene)-3-(3,4-dimethoxyphenyl)-2-phenyl-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3c] Pyridine

1
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Jalan H.R. Subrantas KM. 12.5, Pekanbaru 28293, Indonesia
2
Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Jalan Kamboja, Pekanbaru 28293, Indonesia
*
Author to whom correspondence should be addressed.
Academic Editor: Ian R. Baxendale
Molbank 2021, 2021(3), M1240; https://doi.org/10.3390/M1240
Received: 27 April 2021 / Revised: 2 June 2021 / Accepted: 4 June 2021 / Published: 1 July 2021
A new pyrazolo-pyridine analogue (title compound) was synthesized in two steps. The first stage was synthesis of monoketone curcumin analogue through Claisen–Schmidt reaction. The second stage was synthesis of the title compound through intermolecular cyclization under reflux condition. The structure of the title compound has been confirmed by spectroscopic analysis including UV, FT-IR, HRMS, 1D NMR (1H-NMR, 13C-NMR, 1D-TOCSY), and 2D NMR (COSY, HSQC, HMBC). Based on the DPPH assay, the compound has moderate antioxidant activity, with an IC50 value of 194.06 ± 7.88 µg/mL (0.337 mM). View Full-Text
Keywords: monoketone curcumin analogue; pyrazolo-pyridine analogue; Claisen-Schmidt condensation; intermolecular cyclization; DPPH assay; antioxidant monoketone curcumin analogue; pyrazolo-pyridine analogue; Claisen-Schmidt condensation; intermolecular cyclization; DPPH assay; antioxidant
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MDPI and ACS Style

Mora, E.; Zamri, A.; Teruna, H.Y.; Frimayanti, N.; Ikhtiarudin, I.; Herfindo, N.; Rindiana, E.N. (E)-5-Benzyl-7-(3,4-dimethoxybenzylidene)-3-(3,4-dimethoxyphenyl)-2-phenyl-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3c] Pyridine. Molbank 2021, 2021, M1240. https://doi.org/10.3390/M1240

AMA Style

Mora E, Zamri A, Teruna HY, Frimayanti N, Ikhtiarudin I, Herfindo N, Rindiana EN. (E)-5-Benzyl-7-(3,4-dimethoxybenzylidene)-3-(3,4-dimethoxyphenyl)-2-phenyl-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3c] Pyridine. Molbank. 2021; 2021(3):M1240. https://doi.org/10.3390/M1240

Chicago/Turabian Style

Mora, Enda, Adel Zamri, Hilwan Y. Teruna, Neni Frimayanti, Ihsan Ikhtiarudin, Noval Herfindo, and Elsa N. Rindiana 2021. "(E)-5-Benzyl-7-(3,4-dimethoxybenzylidene)-3-(3,4-dimethoxyphenyl)-2-phenyl-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3c] Pyridine" Molbank 2021, no. 3: M1240. https://doi.org/10.3390/M1240

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