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2-(2-(Fluorosulfonyloxy)phenyl)benzoxazole

1
Kizhner Research Center, Tomsk Polytechnic University, 634050 Tomsk, Russia
2
Scientific Research Institute of Biological Medicine, Altai State University, 656049 Barnaul, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Fawaz Aldabbagh
Molbank 2021, 2021(3), M1242; https://doi.org/10.3390/M1242
Received: 3 June 2021 / Revised: 18 June 2021 / Accepted: 21 June 2021 / Published: 2 July 2021
The fluorosulfate derivatives of benzoxazole attract attention since benzoxazole-based compounds have a wide range of biological activities, and the ability of the –SO2F group to react with various functional groups makes it possible to synthesize various new derivatives. The new 2-(2-(fluorosulfonyloxy)phenyl)benzoxazole (2) has been synthesized by the SuFEx click reaction in a two-chamber reactor. Compound 2 is the first example of a benzoxazole derivative with a fluorosulfate-containing substituent at position two of the benzoxazole heterocycle. The anti-cancer potency of 2 was evaluated in silico using molecular docking. The docking results suggest that title compound 2 is of great interest for further studies as a possible anaplastic lymphoma kinase inhibitor. View Full-Text
Keywords: benzoxazole; SuFEx; molecular docking benzoxazole; SuFEx; molecular docking
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MDPI and ACS Style

Danilenko, N.V.; Shmalyuk, V.I.; Khlebnikov, A.I. 2-(2-(Fluorosulfonyloxy)phenyl)benzoxazole. Molbank 2021, 2021, M1242. https://doi.org/10.3390/M1242

AMA Style

Danilenko NV, Shmalyuk VI, Khlebnikov AI. 2-(2-(Fluorosulfonyloxy)phenyl)benzoxazole. Molbank. 2021; 2021(3):M1242. https://doi.org/10.3390/M1242

Chicago/Turabian Style

Danilenko, Nadezhda V., Vladimir I. Shmalyuk, and Andrei I. Khlebnikov 2021. "2-(2-(Fluorosulfonyloxy)phenyl)benzoxazole" Molbank 2021, no. 3: M1242. https://doi.org/10.3390/M1242

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