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5-(4-Fluorophenyl)-3-(naphthalen-1-yl)-1-phenyl-1H-pyrazole

1
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Jalan H.R. Subrantas KM. 12.5, Pekanbaru 28293, Indonesia
2
Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Jalan Kamboja, Pekanbaru 28293, Indonesia
*
Author to whom correspondence should be addressed.
Academic Editor: Fawaz Aldabbagh
Molbank 2021, 2021(1), M1197; https://doi.org/10.3390/M1197
Received: 9 February 2021 / Revised: 7 March 2021 / Accepted: 7 March 2021 / Published: 10 March 2021
(This article belongs to the Section Organic Synthesis)
A new fluorinated pyrazole, 5-(4-fluorophenyl)-3-(naphthalen-1-yl)-1-phenyl-1H-pyrazole was successfully synthesized via a two-step reaction. Firstly, the synthesis of pyrazoline was performed via one-pot three-component reaction under microwave irradiation. Secondly, the synthesis of pyrazole was performed via oxidative aromatization of pyrazoline under conventional heating. The structure of the synthesized compound was confirmed by spectroscopic analysis, including FT-IR, HR-MS, 1D and 2D NMR analysis. Then, molecular docking study showed that the binding affinity of the synthesized compound to human estrogen alpha receptor (ERα) was close to 4-OHT as a native ligand. View Full-Text
Keywords: fluorinated pyrazole; one-pot reaction; three-component reaction; anti-breast cancer; molecular docking; human estrogen alpha fluorinated pyrazole; one-pot reaction; three-component reaction; anti-breast cancer; molecular docking; human estrogen alpha
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MDPI and ACS Style

Jasril, J.; Frimayanti, N.; Nurulita, Y.; Zamri, A.; Ikhtiarudin, I.; Guntur, G. 5-(4-Fluorophenyl)-3-(naphthalen-1-yl)-1-phenyl-1H-pyrazole. Molbank 2021, 2021, M1197. https://doi.org/10.3390/M1197

AMA Style

Jasril J, Frimayanti N, Nurulita Y, Zamri A, Ikhtiarudin I, Guntur G. 5-(4-Fluorophenyl)-3-(naphthalen-1-yl)-1-phenyl-1H-pyrazole. Molbank. 2021; 2021(1):M1197. https://doi.org/10.3390/M1197

Chicago/Turabian Style

Jasril, Jasril; Frimayanti, Neni; Nurulita, Yuana; Zamri, Adel; Ikhtiarudin, Ihsan; Guntur, Guntur. 2021. "5-(4-Fluorophenyl)-3-(naphthalen-1-yl)-1-phenyl-1H-pyrazole" Molbank 2021, no. 1: M1197. https://doi.org/10.3390/M1197

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