3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione
by
Nadine Uwabagira 1 and Balladka Kunhana Sarojini 1,2,*
Nadine Uwabagira 1 and Balladka Kunhana Sarojini 1,2,*
1
Division of Biochemistry, Department of Studies in Biochemistry, Mangalore University, Mangalore, Karnataka 574199, India
2
Department of Studies in Industrial Chemistry, Mangalore University, Mangalore, Karnataka 574199, India
*
Author to whom correspondence should be addressed.
Molbank 2019, 2019(4), M1083; https://doi.org/10.3390/M1083
Received: 16 August 2019 / Revised: 2 September 2019 / Accepted: 3 September 2019 / Published: 3 October 2019
(This article belongs to the Special Issue Heterocycle Reactions)
The compound 3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione has been designed, synthesized, and screened for its in vitro antibreast cancer activity, using human breast adenocarcinoma cell lines (MCF-7) and in vitro anti-inflammatory activity. By hemolysis assay, it showed that it has a nonhemolytic and nontoxic effect on human blood cell. The title compound 5, subjected to in vitro activities, showed that it is cytotoxic with an IC50 of 42.30 µM and a good anti-inflammatory agent. The docking results against cyclin dependent kinase 2 (CDK2) (PDB ID: 3QQK) gave insights on its inhibitory activity.
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Keywords:
antibreast cancer; anti-inflammator; hemolysis assay; thiazolidinedione; CDK 2
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Uwabagira, N.; Sarojini, B.K. 3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione. Molbank 2019, 2019, M1083.
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