3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione
1
Division of Biochemistry, Department of Studies in Biochemistry, Mangalore University, Mangalore, Karnataka 574199, India
2
Department of Studies in Industrial Chemistry, Mangalore University, Mangalore, Karnataka 574199, India
*
Author to whom correspondence should be addressed.
Molbank 2019, 2019(4), M1083; https://doi.org/10.3390/M1083
Received: 16 August 2019 / Revised: 2 September 2019 / Accepted: 3 September 2019 / Published: 3 October 2019
(This article belongs to the Special Issue Heterocycle Reactions)
The compound 3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione has been designed, synthesized, and screened for its in vitro antibreast cancer activity, using human breast adenocarcinoma cell lines (MCF-7) and in vitro anti-inflammatory activity. By hemolysis assay, it showed that it has a nonhemolytic and nontoxic effect on human blood cell. The title compound 5, subjected to in vitro activities, showed that it is cytotoxic with an IC50 of 42.30 µM and a good anti-inflammatory agent. The docking results against cyclin dependent kinase 2 (CDK2) (PDB ID: 3QQK) gave insights on its inhibitory activity.
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Keywords:
antibreast cancer; anti-inflammator; hemolysis assay; thiazolidinedione; CDK 2
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style
Uwabagira, N.; Sarojini, B.K. 3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione. Molbank 2019, 2019, M1083. https://doi.org/10.3390/M1083
AMA Style
Uwabagira N, Sarojini BK. 3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione. Molbank. 2019; 2019(4):M1083. https://doi.org/10.3390/M1083
Chicago/Turabian StyleUwabagira, Nadine; Sarojini, Balladka K. 2019. "3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione" Molbank 2019, no. 4: M1083. https://doi.org/10.3390/M1083
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