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Division of Biochemistry, Department of Studies in Biochemistry, Mangalore University, Mangalore, Karnataka 574199, India
Department of Studies in Industrial Chemistry, Mangalore University, Mangalore, Karnataka 574199, India
Author to whom correspondence should be addressed.
Molbank 2019, 2019(4), M1083;
Received: 16 August 2019 / Revised: 2 September 2019 / Accepted: 3 September 2019 / Published: 3 October 2019
(This article belongs to the Special Issue Heterocycle Reactions)
The compound 3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione has been designed, synthesized, and screened for its in vitro antibreast cancer activity, using human breast adenocarcinoma cell lines (MCF-7) and in vitro anti-inflammatory activity. By hemolysis assay, it showed that it has a nonhemolytic and nontoxic effect on human blood cell. The title compound 5, subjected to in vitro activities, showed that it is cytotoxic with an IC50 of 42.30 µM and a good anti-inflammatory agent. The docking results against cyclin dependent kinase 2 (CDK2) (PDB ID: 3QQK) gave insights on its inhibitory activity. View Full-Text
Keywords: antibreast cancer; anti-inflammator; hemolysis assay; thiazolidinedione; CDK 2 antibreast cancer; anti-inflammator; hemolysis assay; thiazolidinedione; CDK 2
MDPI and ACS Style

Uwabagira, N.; Sarojini, B.K. 3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione. Molbank 2019, 2019, M1083.

AMA Style

Uwabagira N, Sarojini BK. 3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione. Molbank. 2019; 2019(4):M1083.

Chicago/Turabian Style

Uwabagira, Nadine; Sarojini, Balladka K. 2019. "3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione" Molbank 2019, no. 4: M1083.

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