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Open AccessCommunication

Reactions of Polychlorinated Pyrimidines with DABCO

1
Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenis Str., Engomi, P. O. Box 22006, 1516 Nicosia, Cyprus
2
Department of Chemistry, University of Cyprus, P. O. Box 20537, 1678 Nicosia, Cyprus
*
Author to whom correspondence should be addressed.
Molbank 2019, 2019(4), M1084; https://doi.org/10.3390/M1084
Received: 27 September 2019 / Revised: 11 October 2019 / Accepted: 12 October 2019 / Published: 14 October 2019
The reaction of 2,4,5,6-tetrachloropyrimidine (4) and 4,5,6-trichloropyrimidine-2-carbonitrile (1) with DABCO (1 equiv.), in MeCN, at ca. 20 °C gives 2,4,5-trichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine (5) and 4,5-dichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine-2-carbonitrile (6) in 42% and 52% yields, respectively. The new compounds were fully characterized. View Full-Text
Keywords: heterocycle; piperazine; pyrimidine; DABCO heterocycle; piperazine; pyrimidine; DABCO
MDPI and ACS Style

Kalogirou, A.S.; Koutentis, P.A. Reactions of Polychlorinated Pyrimidines with DABCO. Molbank 2019, 2019, M1084.

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