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Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie gory 1-3, Moscow 119991, Russian
Laboratory of High Technologies, Ltd. Vernadskogo 86, Moscow 119571, Russian
Laboratory of Chemical Synthesis, Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela 1, Moscow 117997, Russian
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky pr. 47, Moscow 119991, Russian
Authors to whom correspondence should be addressed.
Molbank 2019, 2019(2), M1061;
Received: 27 April 2019 / Revised: 13 May 2019 / Accepted: 16 May 2019 / Published: 17 May 2019
(This article belongs to the Collection Molecules from Catalytic Processes)
A simple approach to synthesize 4b,5,6,9-tetrahydro-7H-dibenzo[c,e]pyrrolo[1,2-a]azepin- 7-one has been developed, based on a three-step transformation of 2-(2-bromophenyl)cyclopropane-1,1-diester. The key stage in this method is an intramolecular cross-coupling of 1-(2-bromobenzyl)-5-(2-bromophenyl)pyrrolidin-2-one under continuous flow conditions in an H-Сube-Pro using commercially available supported Pd catalysts. View Full-Text
Keywords: donor-acceptor cyclopropanes; tetrahydrodibenzo[c,e]pyrrolo[1,2-a]azepines; cross-coupling reactions; flow chemistry donor-acceptor cyclopropanes; tetrahydrodibenzo[c,e]pyrrolo[1,2-a]azepines; cross-coupling reactions; flow chemistry
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Boichenko, M.A.; Babkin, I.Y.; Kobylskoy, S.G.; Chagarovskiy, A.O.; Ivanova, O.A.; Trushkov, I.V. 4b,5,6,9-Tetrahydro-7H-dibenzo[c,e]pyrrolo[1,2-a]azepin-7-one. Molbank 2019, 2019, M1061.

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