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4b,5,6,9-Tetrahydro-7H-dibenzo[c,e]pyrrolo[1,2-a]azepin-7-one

1
Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie gory 1-3, Moscow 119991, Russian
2
Laboratory of High Technologies, Ltd. Vernadskogo 86, Moscow 119571, Russian
3
Laboratory of Chemical Synthesis, Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela 1, Moscow 117997, Russian
4
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky pr. 47, Moscow 119991, Russian
*
Authors to whom correspondence should be addressed.
Molbank 2019, 2019(2), M1061; https://doi.org/10.3390/M1061
Received: 27 April 2019 / Revised: 13 May 2019 / Accepted: 16 May 2019 / Published: 17 May 2019
(This article belongs to the Special Issue Molecules from Catalytic Processes)
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Abstract

A simple approach to synthesize 4b,5,6,9-tetrahydro-7H-dibenzo[c,e]pyrrolo[1,2-a]azepin- 7-one has been developed, based on a three-step transformation of 2-(2-bromophenyl)cyclopropane-1,1-diester. The key stage in this method is an intramolecular cross-coupling of 1-(2-bromobenzyl)-5-(2-bromophenyl)pyrrolidin-2-one under continuous flow conditions in an H-Сube-Pro using commercially available supported Pd catalysts. View Full-Text
Keywords: donor-acceptor cyclopropanes; tetrahydrodibenzo[c,e]pyrrolo[1,2-a]azepines; cross-coupling reactions; flow chemistry donor-acceptor cyclopropanes; tetrahydrodibenzo[c,e]pyrrolo[1,2-a]azepines; cross-coupling reactions; flow chemistry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Boichenko, M.A.; Babkin, I.Y.; Kobylskoy, S.G.; Chagarovskiy, A.O.; Ivanova, O.A.; Trushkov, I.V. 4b,5,6,9-Tetrahydro-7H-dibenzo[c,e]pyrrolo[1,2-a]azepin-7-one. Molbank 2019, 2019, M1061.

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