Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment

Lee, Eun Chae; Ha, Tae Won; Lee, Dong-Hun; Hong, Dong-Yong; Park, Sang-Won; Lee, Ji Young; Lee, Man Ryul; Oh, Jae Sang

doi:10.3390/ijms23158367

Open AccessReview

Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment

by

Eun Chae Lee

^1,2,†,

Tae Won Ha

^2,†

,

Dong-Hun Lee

^1,2

,

Dong-Yong Hong

^1,2

,

Sang-Won Park

^1,2

,

Ji Young Lee

¹,

Man Ryul Lee

^2,*

and

Jae Sang Oh

^1,*

¹

Department of Neurosurgery, College of Medicine, Cheonan Hospital, Soonchunhyang University, Cheonan 31151, Korea

²

Soonchunhyang Institute of Medi-Bio Science (SIMS), Soon Chun Hyang University, Cheonan 31151, Korea

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2022, 23(15), 8367; https://doi.org/10.3390/ijms23158367

Submission received: 5 July 2022 / Revised: 23 July 2022 / Accepted: 26 July 2022 / Published: 28 July 2022

(This article belongs to the Special Issue Exosomes)

Download

Browse Figures

Review Reports Versions Notes

Abstract

Stroke is the leading cause of death and neurological disorders worldwide. However, diagnostic techniques and treatments for stroke patients are still limited for certain types of stroke. Intensive research has been conducted so far to find suitable diagnostic techniques and treatments, but so far there has been no success. In recent years, various studies have drawn much attention to the clinical value of utilizing the mechanism of exosomes, low toxicity, biodegradability, and the ability to cross the blood–brain barrier. Recent studies have been reported on the use of biomarkers and protective and recovery effects of exosomes derived from stem cells or various cells in the diagnostic stage after stroke. This review focuses on publications describing changes in diagnostic biomarkers of exosomes following various strokes and processes for various potential applications as therapeutics.

Keywords: extracellular vesicles; exosome; stroke; ischemic stroke; hemorrhagic stroke; exosome isolation

Graphical Abstract

Share and Cite

MDPI and ACS Style

Lee, E.C.; Ha, T.W.; Lee, D.-H.; Hong, D.-Y.; Park, S.-W.; Lee, J.Y.; Lee, M.R.; Oh, J.S. Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment. Int. J. Mol. Sci. 2022, 23, 8367. https://doi.org/10.3390/ijms23158367

AMA Style

Lee EC, Ha TW, Lee D-H, Hong D-Y, Park S-W, Lee JY, Lee MR, Oh JS. Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment. International Journal of Molecular Sciences. 2022; 23(15):8367. https://doi.org/10.3390/ijms23158367

Chicago/Turabian Style

Lee, Eun Chae, Tae Won Ha, Dong-Hun Lee, Dong-Yong Hong, Sang-Won Park, Ji Young Lee, Man Ryul Lee, and Jae Sang Oh. 2022. "Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment" International Journal of Molecular Sciences 23, no. 15: 8367. https://doi.org/10.3390/ijms23158367

APA Style

Lee, E. C., Ha, T. W., Lee, D.-H., Hong, D.-Y., Park, S.-W., Lee, J. Y., Lee, M. R., & Oh, J. S. (2022). Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment. International Journal of Molecular Sciences, 23(15), 8367. https://doi.org/10.3390/ijms23158367

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI