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Open AccessArticle

Increased Histone Acetylation and Decreased Expression of Specific Histone Deacetylases in Ultraviolet-Irradiated and Intrinsically Aged Human Skin In Vivo

by 1,2,3,†, 1,3,†, 1,3, 1,3, 1,2,3, 1,3,* and 1,2,3,4,*
1
Department of Dermatology, Seoul National University College of Medicine, Seoul 03080, Korea
2
Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Korea
3
Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul 03080, Korea
4
Institute on Aging, Seoul National University, Seoul 03080, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Andrzej Slominski
Int. J. Mol. Sci. 2021, 22(4), 2032; https://doi.org/10.3390/ijms22042032
Received: 20 January 2021 / Revised: 13 February 2021 / Accepted: 16 February 2021 / Published: 18 February 2021
(This article belongs to the Special Issue Skin Inflammation Aging and Diseases)
Histone deacetylases (HDACs) are conserved enzymes that remove acetyl groups from lysine side chains in histones and other proteins and play a crucial role in epigenetic regulation. Previously, we showed that histone acetylation is implicated in ultraviolet (UV)-induced inflammation and matrix impairment. To elucidate the histone acetylation status and specific HDACs involved in skin aging, we examined the changes in histone acetylation, global HDAC activity, and the expression of HDACs and sirtuins (SIRTs) in intrinsically aged and photoaged human skin as well as in UV-irradiated human skin in vivo. Following acute UV irradiation, the acetylated histone H3 (AcH3) level was increased, but HDAC activity and the expression levels of HDAC4, HDAC11, and SIRT4 were significantly decreased. In intrinsically aged skin, AcH3 levels were increased, but HDAC activity and the expression levels of HDAC4, HDAC5, HDAC10, HDAC11, SIRT6, and SIRT7 were significantly decreased. However, histone acetylation and HDAC expression in photoaged skin were not significantly different from those in intrinsically aged skin. Collectively, HDAC4 and HDAC11 were decreased in both UV-irradiated and intrinsically aged skin, suggesting that they may play a universal role in increased histone acetylation associated with skin aging. View Full-Text
Keywords: histone deacetylase; sirtuin; ultraviolet; acetylated histone H3; skin aging histone deacetylase; sirtuin; ultraviolet; acetylated histone H3; skin aging
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MDPI and ACS Style

Lee, Y.; Shin, M.H.; Kim, M.-K.; Kim, Y.K.; Shin, H.S.; Lee, D.H.; Chung, J.H. Increased Histone Acetylation and Decreased Expression of Specific Histone Deacetylases in Ultraviolet-Irradiated and Intrinsically Aged Human Skin In Vivo. Int. J. Mol. Sci. 2021, 22, 2032. https://doi.org/10.3390/ijms22042032

AMA Style

Lee Y, Shin MH, Kim M-K, Kim YK, Shin HS, Lee DH, Chung JH. Increased Histone Acetylation and Decreased Expression of Specific Histone Deacetylases in Ultraviolet-Irradiated and Intrinsically Aged Human Skin In Vivo. International Journal of Molecular Sciences. 2021; 22(4):2032. https://doi.org/10.3390/ijms22042032

Chicago/Turabian Style

Lee, Yuri; Shin, Mi H.; Kim, Min-Kyoung; Kim, Yeon K.; Shin, Hye S.; Lee, Dong H.; Chung, Jin H. 2021. "Increased Histone Acetylation and Decreased Expression of Specific Histone Deacetylases in Ultraviolet-Irradiated and Intrinsically Aged Human Skin In Vivo" Int. J. Mol. Sci. 22, no. 4: 2032. https://doi.org/10.3390/ijms22042032

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