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Article

MWNTs or PEG as Stability Enhancers for DNA–Cationic Surfactant Gel Particles

by and *
Departament de Tensioactius i Nanobiotecnologia, Institut de Química Avançada de Catalunya, IQAC-CSIC, C/Jordi Girona 18-26, 08034 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Present address: Johnson Controls, Building Technologies and Solutions, Industriestr 13, 68526 Ladenburg, Germany.
Academic Editor: Gerardo Prieto 
Int. J. Mol. Sci. 2021, 22(16), 8801; https://doi.org/10.3390/ijms22168801
Received: 8 July 2021 / Revised: 10 August 2021 / Accepted: 12 August 2021 / Published: 16 August 2021
(This article belongs to the Special Issue Surfactants, Colloids, and Soft Nanomaterials)
Cationic surfactants interact with DNA (Deoxyribonucleic acid), forming surfactant-DNA complexes that offer particularly efficient control for encapsulation and release of DNA from DNA gel particles. In the present work, DNA-based particles were prepared using CTAB (Cetyltrimethylammonium bromide) as the cationic surfactant and modified using two different additives: (Multi-Walled Carbon Nanotubes) MWNT or PEG (Poly Ethylene Glycol). The use of both additives to form composites increased the stability of the gel particles. The stability was monitored by the release of DNA and CTAB in different pH solutions. However, not much is known about the influence of pH on DNA–surfactant interaction and the release of DNA and surfactant from gel particles. It was observed that the solubilization of DNA occurs only in very acid media, while that of CTAB does not depend on pH and gets to a plateau after about 8 h. Within 2 h in contact with a pH = 2 solution, about 1% DNA and CTAB was released. Complete destruction for the gel particles was observed in pH = 2 solution after 17 days for PEG and 20 days for MWNT. The composite particles show a considerably enlarged sustained release span compared to the unmodified ones. The dehydration-rehydration studies show that the structure of the composite gel particles, as determined from SAXS (Small-Angle-X-Ray-Scattering) experiments, is similar to that of the unmodified ones. These studies will allow a better knowledge of these particles’ formation and evolution in view of possible applications in drug delivery and release. View Full-Text
Keywords: DNA; multi-walled carbon nanotubes; PEG; composite; release; stability; SAXS DNA; multi-walled carbon nanotubes; PEG; composite; release; stability; SAXS
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MDPI and ACS Style

Mezei, A.; Pons, R. MWNTs or PEG as Stability Enhancers for DNA–Cationic Surfactant Gel Particles. Int. J. Mol. Sci. 2021, 22, 8801. https://doi.org/10.3390/ijms22168801

AMA Style

Mezei A, Pons R. MWNTs or PEG as Stability Enhancers for DNA–Cationic Surfactant Gel Particles. International Journal of Molecular Sciences. 2021; 22(16):8801. https://doi.org/10.3390/ijms22168801

Chicago/Turabian Style

Mezei, Amalia, and Ramon Pons. 2021. "MWNTs or PEG as Stability Enhancers for DNA–Cationic Surfactant Gel Particles" International Journal of Molecular Sciences 22, no. 16: 8801. https://doi.org/10.3390/ijms22168801

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